Method and apparatus for improving delivery of an agent to a kidney

• US 9,149,610 B2
• Filed: 06/13/2011
• Issued: 10/06/2015
• Est. Priority Date: 05/31/2007
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Consigny, Paul M, Shen, Randy, Nguyen, Binh T, Leonard, Michael J
• Primary Examiner(s): Mehta, Bhisma
• Assistant Examiner(s): LEE, BRANDY SCOTT
• Application Number:
  US13/158,757
• Publication Number:
  US 20110245766A1
• Time in Patent Office: 1,576 Days
• Field of Search: 604/509, 604/523, 604 9601-10314
• US Class Current: 1/1
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61L 2300/432 Inhibitors, antagonists A61L2300/402 - A61L2300/43 take precedence
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow general flow characteristics A61M2206/10
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2206/14 Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
• CPC Class Codes: A61M 25/04 in the body, e.g. expansible A61M25/10, A61M16/0488 take precedence
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members.

Claims

1. A device comprising:

a catheter including;

a main body,

a self-expanding diffusion member connected to the main body, the self-expanding diffusion member having (1) a closed proximal portion operable to hold a fluid therein;

(2) a distal facing surface that is defined by an edge joining the distal facing surface to the closed proximal portion, and (3) a plurality of delivery ports formed within the distal facing surface, and wherein the self-expanding diffusion member is dimensioned to provide from 60 percent to 90 percent occlusion of a blood vessel of a mammal, and

a drug delivery lumen located in the main body, wherein the drug delivery lumen is in fluid communication with the drug delivery ports via the closed proximal portion such that a drug can be delivered from the plurality of delivery ports in a generally distal direction,

wherein the device is adapted for percutaneous delivery into the vasculature of a mammal and adapted to expand the self-expanding diffusion member within the vessel.

2. The device of claim 1 wherein the drug delivery lumen is proximal to the self-expanding diffusion member.

3. The device of claim 1 wherein the self-expanding diffusion member has a diameter between 60 and 90 percent of the vessel diameter.

4. The device of claim 1 wherein the device further comprises a deployment sheath that is movably affixed substantially coaxially to the main body.

5. The device of claim 4 wherein the self-expanding diffusion member is connected to a distal end of the main body at the closed proximal portion of the self-expanding diffusion member.

6. A device comprising a catheter including

a main body,

an expandable diffusion member connected to the main body, the expandable diffusion member having a proximal end and a distal end, and wherein the proximal end is closed such that the proximal end is operable to occlude a blood vessel within which the device is positioned and the distal end forms a distal facing surface that is defined by an edge, the distal facing surface having a plurality of delivery ports facing a generally distal direction, and

a drug delivery lumen located in the expandable diffusion member and terminating at a point proximal to the face, wherein the drug delivery lumen is in fluid communication with the drug delivery ports such that a drug can be delivered from the plurality of delivery ports in a generally distal direction,

wherein the device is adapted for percutaneous delivery into the vasculature of a mammal and adapted to expand the expandable diffusion member within a blood vessel of a mammal.

7. The device of claim 6 wherein the expandable diffusion member has a diameter between 20 and 95 percent, 40 and 93 percent, or 60 and 90 percent of the vessel diameter.

8. The device of claim 6 wherein the expandable diffusion member comprises tabs attached near the edge, which is between the distal end of the expandable diffusion member and sides of the proximal end of the expandable diffusion member.

9. The device of claim 6 wherein the distal end comprises four or more delivery ports.