Method and system for predicting spatial and temporal distributions of therapeutic substance carriers
First Claim
1. A method for predicting spatial and temporal distributions of therapeutic substance carriers within a body, comprising:
- at a computing system, receiving an image dataset and a spectra dataset of a drug carrier;
at the computing system, transforming the image dataset and the spectra dataset into a set of characteristics, wherein the set of characteristics comprises electrotopological characteristics, connectivity characteristics, molecular characteristics, and geometrical characteristics;
generating a set of descriptors based upon the set of characteristics and a set of encoding functions;
at the computing system, transforming the set of descriptors into a set of pharmacokinetic parameters and a set of pharmacodynamic parameters for the therapeutic substance carrier based upon a transformation model;
at the computing system, transforming the set of pharmacokinetic parameters and the set of pharmacodynamic parameters into a spatial distribution and a temporal profile of the therapeutic substance carrier based upon a predictive model; and
mapping the spatial distribution and the temporal profile onto at least a portion of an organ system of the user, thereby characterizing at least one of a concentration of the therapeutic substance carrier and a concentration of a therapeutic substance carried by the drug carrier in the organ system within a time window.
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Abstract
A method and system for predicting spatial and temporal distributions of therapeutic substance carriers within a body of a user, comprising: at a computing system, receiving an image dataset and a spectra dataset of a therapeutic substance carrier generated from at least one of an imaging model and a spectra-generating module; transforming the image dataset and the spectra dataset into a set of characteristics, wherein the set of characteristics comprises electrotopological characteristics and geometrical characteristics; generating a set of pharmacokinetic parameters and a set of pharmacodynamic parameters for the therapeutic substance carrier based upon the set of characteristics and a transformation model; and transforming the set of pharmacokinetic parameters and the set of pharmacodynamic parameters into a spatial distribution and a temporal profile of the therapeutic substance carrier, based upon a predictive model incorporating physiological parameters of the body, thereby predicting distributions of the therapeutic substance carrier within the body.
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Citations
20 Claims
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1. A method for predicting spatial and temporal distributions of therapeutic substance carriers within a body, comprising:
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at a computing system, receiving an image dataset and a spectra dataset of a drug carrier; at the computing system, transforming the image dataset and the spectra dataset into a set of characteristics, wherein the set of characteristics comprises electrotopological characteristics, connectivity characteristics, molecular characteristics, and geometrical characteristics; generating a set of descriptors based upon the set of characteristics and a set of encoding functions; at the computing system, transforming the set of descriptors into a set of pharmacokinetic parameters and a set of pharmacodynamic parameters for the therapeutic substance carrier based upon a transformation model; at the computing system, transforming the set of pharmacokinetic parameters and the set of pharmacodynamic parameters into a spatial distribution and a temporal profile of the therapeutic substance carrier based upon a predictive model; and mapping the spatial distribution and the temporal profile onto at least a portion of an organ system of the user, thereby characterizing at least one of a concentration of the therapeutic substance carrier and a concentration of a therapeutic substance carried by the drug carrier in the organ system within a time window. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for predicting spatial and temporal distributions of therapeutic substance carriers within a body of a user, comprising:
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at a computing system, receiving an image dataset and a spectra dataset of a therapeutic substance carrier generated from at least one of an imaging module and a spectra-generating module; at the computing system, transforming the image dataset and the spectra dataset into a set of characteristics, wherein the set of characteristics comprises electrotopological characteristics and geometrical characteristics; at the computing system, generating a set of pharmacokinetic parameters and a set of pharmacodynamic parameters for the therapeutic substance carrier based upon the set of characteristics and a transformation model; and at the computing system, transforming the set of pharmacokinetic parameters and the set of pharmacodynamic parameters into a spatial distribution and a temporal profile of the therapeutic substance carrier, based upon a predictive model incorporating physiological parameters of the body, thereby predicting distributions of the therapeutic substance carrier within the body. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for predicting distributions of therapeutic substance carriers within a body, comprising:
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at a computing system, receiving a dataset of a therapeutic substance carrier generated from at least one of an imaging module and a spectra-generating module; at the computing system, transforming the dataset into a set of characteristics, wherein the set of characteristics comprises at least one of electrotopological characteristics and geometrical characteristics; at the computing system, generating a set of parameters for the therapeutic substance carrier based upon the set of characteristics and a transformation model; and at the computing system, transforming the set of parameters into a spatial distribution and a temporal profile of the therapeutic substance carrier based upon a predictive module incorporating physiological parameters of the body, thereby predicting distributions of the therapeutic substance carrier within the body. - View Dependent Claims (20)
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Specification