Methods and apparatus for calibrating respiratory effort from photoplethysmograph signals

• US 9,155,493 B2
• Filed: 04/30/2010
• Issued: 10/13/2015
• Est. Priority Date: 10/03/2008
• Status: Active Grant

• Current Assignee: Nellcor Puritan Bennett Ireland
• Original Assignee: Nellcor Puritan Bennett Ireland
• Inventors: Addison, Paul Stanley, Watson, James N.
• Primary Examiner(s): Cheng, Jacqueline
• Assistant Examiner(s): Agahi, Puya
• Application Number:
  US12/771,792
• Publication Number:
  US 20110270114A1
• Time in Patent Office: 1,992 Days
• Field of Search: 600/484, 600/529, 600/533, 600/538, 600/532, 600/535, 600/537, 600/540, 600/543
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/726 using Wavelet transforms

Abstract

Breathing effort of a patient, as determined (for example) from a photoplethysmograph (“PPG”) signal from the patient, can be calibrated in relation to air pressure in the patient'"'"'s respiratory system. This calibration can be done by subjecting the patient to varying amounts of breathing resistance; and for each such amount, concurrently measuring (1) air pressure in the respiratory system (e.g., in the oral/nasal cavity) and (2) breathing effort (from the PPG signal). Use can be made of this calibration, e.g., during a sleep study of the patient. During such a study, breathing effort, again determined from the PPG signal and occurring, for example, during an apneic event of the patient, can be used to infer air pressure in the respiratory system by using the above calibration.

Claims

1. A method of calibrating respiratory effort of a patient for determining oral/nasal pressure, comprising:

using a pressure sensor when the patient is awake to measure air pressure in the patient'"'"'s oral/nasal cavity during breathing with each of a plurality of successive different amounts of resistance to breathing to produce an oral/nasal pressure signal value for each respective amount of breathing resistance;

using respiratory effort monitoring apparatus when the patient is awake to acquire a respiratory effort signal from the patient during breathing with each of the plurality of successive amounts of resistance to breathing;

using respiratory effort signal processing circuitry to determine from the respiratory effort signal for each of the plurality of successive amounts of resistance to breathing a respective breathing effort signal value;

using storage circuitry to store a correlation between each oral/nasal pressure signal value and the breathing effort signal value concurrent with that respective oral/nasal pressure signal value, wherein the correlation is generated based on the plurality of successive amounts of resistance to breathing;

using the respiratory effort monitoring apparatus to acquire a respiratory effort signal from the patient while asleep;

using the respiratory effort signal processing circuitry to determine from the respiratory effort signal from the sleeping patient at least one breathing effort signal value for the sleeping patient;

using processing circuitry to determine a value indicative of the patient'"'"'s oral/nasal pressure based on the stored correlation and the at least one breathing effort signal value determined for the sleeping patient; and

outputting using a display the value indicative of oral/nasal pressure for the sleeping patient in human-readable form.

2. The method defined in claim 1 wherein the using respiratory effort signal processing circuitry comprises:

producing scalogram signals representing a scalogram of the respiratory effort signal;

analyzing the scalogram signals to identify breathing band signals in the scalogram signals; and

determining a breathing band amplitude signal value as an indication of breathing effort.

3. The method defined in claim 1 further comprising:

using a breathing resistance apparatus to subject the patient to the successive different amounts of resistance to breathing.

4. The method defined in claim 3 wherein the using the breathing resistance apparatus comprises:

applying the breathing resistance apparatus to the patient so that the patient can only breathe through an air flow passageway through the breathing resistance apparatus.

5. The method defined in claim 4 wherein the using the breathing resistance apparatus further comprises:

varying size of the air flow passageway through the breathing resistance apparatus to subject the patient to the successive different amounts of resistance to breathing.

6. The method defined in claim 1 wherein the using a pressure sensor comprises:

placing the pressure sensor in the patient'"'"'s mouth.

7. The method defined in claim 1 wherein the using respiratory effort monitoring apparatus comprises:

using a photoplethysmograph (“

PPG”

) monitoring apparatus.