Delivery system for ocular implant

• US 9,155,656 B2
• Filed: 02/10/2014
• Issued: 10/13/2015
• Est. Priority Date: 04/24/2012
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Transcend Medical Incorporated (Alcon Incorporated)
• Inventors: Schaller, Michael, Lari, David, Clauson, Luke, White, Nathan, Lilly, Richard S., Newell, Matthew, Ahmed, Iqbal Ike K.
• Primary Examiner(s): MARCETICH, ADAM M
• Application Number:
  US14/176,918
• Publication Number:
  US 20140155805A1
• Time in Patent Office: 610 Days
• US Class Current: 1/1
• CPC Class Codes: A61F 2/167 with pushable plungers
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2002/9505 having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
• CPC Class Codes: A61F 2002/9511 the retaining means being filaments or wires
• CPC Class Codes: A61F 2009/00891 Glaucoma
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2025/09141 made of shape memory alloys which take a particular shape at a certain temperature
• CPC Class Codes: A61M 2025/09175 having specific characteristics at the distal tip
• CPC Class Codes: A61M 2025/09183 having tools at the distal tip
• CPC Class Codes: A61M 2025/09191 made of twisted wires
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 25/09 Guide wires
• CPC Class Codes: A61M 25/0905 extendable, e.g. mechanisms for extension
• CPC Class Codes: A61M 5/3257 Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means

Abstract

A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

Claims

1. A delivery system for delivering an ocular implant into an eye, the delivery system comprising:

a proximal handle portion;

a delivery portion coupled to the handle portion, the delivery portion configured to releasably couple to an ocular implant, the delivery portion including a retractable guidewire that fits through an inner lumen of the ocular implant such that only the guidewire is inserted through the inner lumen of the ocular implant when the ocular implant is attached to the guidewire;

wherein the guidewire includes at least one non-spiraled curved section for providing an interference fit between the guidewire and an inner lumen of the ocular implant when the ocular implant is mounted on the guidewire to assist in retaining the implant on the guidewire during delivery into the eye, wherein the curved section of the guidewire is confined along a discrete section of the guidewire such that the discrete section of the guidewire forms a radius of curvature that is tighter than a radius of curvature of the entire guidewire and wherein the guidewire comprises at least two curved sections, the curved sections being spaced from one another a distance of about 0.0100 inch to 0.0200 inch along the length of the guidewire;

an actuator that actuates to cause an ocular implant coupled to the delivery portion to release from the delivery portion upon actuation of the actuator;

a dampener coupled to the handle portion, the dampener adapted to dampen retraction of the guidewire upon actuation of the actuator.

2. The delivery system of claim 1, wherein the delivery portion further includes a sheath positioned axially over at least a portion of the guidewire.

3. The delivery system of claim 1, wherein the guidewire comprises an s-shape.

4. The delivery system of claim 1, wherein the guidewire comprises a sinusoidal curve shape.

5. The delivery system of claim 1, wherein, when the implant has been delivered into the eye, actuation of the actuator causes the guidewire to withdraw from the ocular implant in a proximal direction.

6. The delivery system of claim 5, wherein the delivery portion further includes a sheath positioned axially over at least a portion of the guidewire and wherein a distal end of the sheath abuts a proximal end of an ocular implant when the ocular implant is positioned on the guidewire, and wherein the distal end of the sheath prevents the ocular implant from moving toward the handle portion as the guidewire withdraws in a proximal direction.

7. The delivery system of claim 6, wherein the non-spiraled curved section of the guidewire retracts into the sheath.

8. The delivery system of claim 1, wherein the guidewire includes at least one inner lumen.

9. The delivery system of claim 8, wherein the guidewire includes at least one opening that provides fluid communication between the inner lumen of the guidewire and an area surrounding the guidewire.

10. The delivery system of claim 9, wherein the area surrounding the guidewire comprises an inner lumen of an ocular implant.

11. The delivery system of claim 1, wherein the delivery system includes at least one fluid delivery feature which delivers fluid from a fluid source and into an inner lumen of the guidewire.

12. The delivery system of claim 11, wherein the fluid from the fluid source includes one or more of a viscoelastic, a drug and a stem cell.

13. The delivery system of claim 1, further comprising an ocular implant formed of a tubular structure having an internal lumen.

14. The delivery system of claim 1, wherein the ocular implant is configured to drain fluid from an anterior chamber of an eye to a supraciliary space of an eye.

15. The delivery system of claim 1, wherein a distal portion of the guidewire is configured to separate a ciliary body of the eye from a sclera of the eye.

16. The delivery system of claim 1, wherein the actuator includes a mechanism that includes a spring, the spring being coupled to the guidewire.

17. The delivery system of claim 16, wherein actuation of the actuator causes the spring to move the guidewire between a first position and a second position relative to the handle portion.

18. The delivery system of claim 1, wherein actuation of the actuator causes the spring to move the guidewire in a proximal direction relative to the handle portion.

19. The delivery system of claim 1, wherein the curved portion of the guidewire has a nominal longitudinal axis and one or more wire peaks separated from the nominal longitudinal axis, wherein each of the peaks contacts an inner surface of the ocular implant to assist in retaining the implant on the guidewire during delivery into the eye.