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Long lasting drug formulations

  • US 9,155,749 B2
  • Filed: 09/12/2007
  • Issued: 10/13/2015
  • Est. Priority Date: 09/14/2006
  • Status: Expired due to Fees
First Claim
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1. A long-lasting therapeutic formulation for implanting into an immunocompetent human subject comprising a genetically modified dermal micro-organ, wherein said micro-organ is transduced in vitro with a helper-dependent adenoviral (HdAd) vector or with an adeno-associated viral (AAV) vector comprising a nucleic acid sequence encoding a therapeutic erythropoietin polypeptide operably linked to one or more regulatory sequences, wherein said nucleic acid sequence is greater than 95% homologous to SEQ ID No:

  • 1, wherein following said transduction in vitro expression of said therapeutic polypeptide is determined, and wherein implantation of said long-lasting formulation in said immunocompetent human subject provides a beneficial effect selected from the group consisting of;

    a. an increase in expression levels of said therapeutic erythropoietin in the subject'"'"'s serum compared with pre-implantation basal levels; and

    b. an alleviation of a symptom of a disease or disorder in said subject, wherein said alleviation persists for greater than one month.

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