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Treatment of ABCA1 gene related diseases by inhibition of a natural antisense transcript to ABCA1

  • US 9,155,754 B2
  • Filed: 05/06/2010
  • Issued: 10/13/2015
  • Est. Priority Date: 05/06/2009
  • Status: Active Grant
First Claim
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1. A method of upregulating a function of and/or the expression of an ABCA1 polynucleotide having SEQ ID NO:

  • 1 in patient cells or tissues in vivo or in sum comprising;

    contacting said cells or tissues with at least one modified single stranded antisense compound of 12 to 30 nucleotides in length that targets and specifically hybridizes to a complementary region of a natural antisense polynucleotide of the ABCA1 polynucleotide having SEQ ID NO;

    8 or 9;

    thereby upregulating function of and/or the expression of the ABCA1 polynucleotide in patient cells or tissues in vivo or in vitro.

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