Boronic acid derivatives and therapeutic uses thereof

• US 9,156,858 B2
• Filed: 05/21/2013
• Issued: 10/13/2015
• Est. Priority Date: 05/23/2012
• Status: Expired due to Fees

• Current Assignee: The Medicines Company (San Diego), LLC. (Novartis Ag)
• Original Assignee: Rempex Pharmaceuticals, Inc (Melinta Therapeutics, Inc.)
• Inventors: Reddy, Raja, Glinka, Tomasz, Totrov, Maxim, Hecker, Scott
• Primary Examiner(s): Balasubramanian, Venkataraman
• Application Number:
  US13/898,959
• Publication Number:
  US 20130316978A1
• Time in Patent Office: 875 Days
• Field of Search: 544/229, 546/13, 548/110, 514/64
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/427 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 31/69 Boron compounds
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: C07F 5/025 Boronic and borinic acid compounds
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.

Claims

1. A compound having the structure selected from the group consisting of:

2. A compound having the structure: