Systems and methods for freezing, storing and thawing biopharmaceutical materials
First Claim
1. A method for use in freezing, storing and thawing biopharmaceutical materials, the method comprising:
- connecting a container for holding biopharmaceutical materials to a holder by receiving the container in a cavity of a cradle of the holder, the cradle formed by a first portion and a second portion of the holder;
the first portion having a first bottom and first edges extending from the first bottom and forming a first inner rim, the first bottom and the first edges bounding the cavity, the inner rim extending completely around a perimeter of the container, the first inner rim comprising longitudinal sides, ends, and curved corners surrounding the perimeter, each of the corners connecting a longitudinal side of the longitudinal sides to an end of the ends, the container contacting the first bottom, the first edges, and at least one corner of the corners;
the second portion comprising a second bottom bounding the cavity opposite the first bottom and second edges extending from the second bottom and bounding the cavity;
the first edges and the second edges comprising concave surfaces bounding the cavity; and
engaging a first plurality of outer teeth of an outer rim of the holder with a second plurality of outer teeth of a second outer rim of a second holder to stack the holder and the second holder and to inhibit movement between the holder and second holder.
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Abstract
A system for using freezing, storing and thawing biopharmaceutical materials which includes a holder and a container for holding biopharmaceutical materials therein. The holder has a cavity and the container is received in the cavity. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior cradle having a bottom and edges extending from the bottom. The cradle bounds the cavity. An outer rim is connected to the cradle and separated from the cavity. The bottom includes an inner surface facing the cavity receiving the container and an outer surface. The outer surface of the bottom is recessed relative to an outer surface of the outer rim.
114 Citations
3 Claims
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1. A method for use in freezing, storing and thawing biopharmaceutical materials, the method comprising:
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connecting a container for holding biopharmaceutical materials to a holder by receiving the container in a cavity of a cradle of the holder, the cradle formed by a first portion and a second portion of the holder; the first portion having a first bottom and first edges extending from the first bottom and forming a first inner rim, the first bottom and the first edges bounding the cavity, the inner rim extending completely around a perimeter of the container, the first inner rim comprising longitudinal sides, ends, and curved corners surrounding the perimeter, each of the corners connecting a longitudinal side of the longitudinal sides to an end of the ends, the container contacting the first bottom, the first edges, and at least one corner of the corners; the second portion comprising a second bottom bounding the cavity opposite the first bottom and second edges extending from the second bottom and bounding the cavity; the first edges and the second edges comprising concave surfaces bounding the cavity; and engaging a first plurality of outer teeth of an outer rim of the holder with a second plurality of outer teeth of a second outer rim of a second holder to stack the holder and the second holder and to inhibit movement between the holder and second holder. - View Dependent Claims (2, 3)
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Specification