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Solvent cast film sustained release latanoprost implant

  • US 9,161,929 B2
  • Filed: 03/20/2014
  • Issued: 10/20/2015
  • Est. Priority Date: 04/29/2011
  • Status: Active Grant
First Claim
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1. A method of treating open-angle glaucoma or ocular hypertension comprising(1) inserting into an eye of a patient in need of such treatment a rolled biodegradable film, wherein the film is rolled into a cylindrical shape, and wherein the insertion of the film is performed using a needle and syringe;

  • (2) allowing the rolled film, once inserted into the eye, to unfurl to its original shape to thereby expose its entire surface to provide for drug diffusion out of the film and into the eye;

    thereby lowering the intraocular pressure of the eye;

    wherein the film consists of about 30% by weight latanoprost, about 35% by weight R208, which is an ester terminated poly(D,L-lactide) having an inherent viscosity of about 1.8-2.2 dl/g, and about 35% by weight RG755, which is an ester terminated poly(D,L-lactide-co-glycolide) having an inherent viscosity of about 0.50-0.70 dl/g and a D,L-lactide;

    glycolide ratio of about 75;

    25.

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