Neuronal protection by cerium oxide nanoparticles

• US 9,161,950 B2
• Filed: 09/21/2012
• Issued: 10/20/2015
• Est. Priority Date: 09/21/2011
• Status: Active Grant

• Current Assignee: University of Central Florida Research Foundation Inc. (State University System of Florida)
• Original Assignee: University Of Central Florida Foundation, Inc.
• Inventors: Self, William T., Bossy-Wetzel, Ella, Seal, Sudipta, Dowding, Janet
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): AL-AWADI, DANAH J
• Application Number:
  US13/624,485
• Publication Number:
  US 20130251756A1
• Time in Patent Office: 1,124 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 33/244 Lanthanides; Compounds thereof medicinal preparations containing radioactive lanthanides for use in therapy or testing in vivo A61K51/00

Abstract

A method of treating a subject with elevated levels of peroxynitrite includes administering a therapeutically effective amount of cerium oxide nanoparticles to the subject, wherein the cerium oxide nanoparticles reduce the level of peroxynitrite in the subject.

Claims

1. A method of treating a subject with elevated levels of peroxynitrite, comprising:

administering a therapeutically effective amount of cerium oxide nanoparticles to the subject, wherein the cerium oxide nanoparticles reduce the level of peroxynitrite in the subject;

wherein the cerium oxide nanoparticles comprise more Ce³⁺ than Ce⁴⁺.

2. The method of claim 1, wherein the cerium oxide nanoparticles range between 1-5 nanometers in size.

3. The method of claim 1, wherein the cerium oxide nanoparticles range between 5-10 nanometers in size.

4. The method of claim 1, wherein said cerium oxide nanoparticles scavenge peroxynitrite.

5. A method of reducing brain inflammation in a patient, comprising:

administering a therapeutically effective amount of cerium oxide

nanoparticles to the patient, said cerium oxide nanoparticles effective to reduce peroxynitrite levels in the brain;

wherein the cerium oxide nanoparticles comprise more Ce³⁺ than Ce⁴⁺.

6. The method of claim 5 wherein the cerium oxide nanoparticles comprise a higher 3+/4+ratio.