Method and system for stimulating a heart

• US 9,162,066 B2
• Filed: 05/31/2011
• Issued: 10/20/2015
• Est. Priority Date: 05/31/2011
• Status: Active Grant

• Current Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Inventors: Hedberg, Sven-Erik, Holmstrom, Nils, Jarverud, Karin
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US13/508,968
• Publication Number:
  US 20140257423A1
• Time in Patent Office: 1,603 Days
• Field of Search: 607/27
• US Class Current: 1/1
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A first ventricle is stimulated at a stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node is computed. A similar process is used to compute a second activation time interval for the other ventricle. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined.

Claims

1. A method for determining cardiac pacing therapy using an implantable cardiac stimulation device, said method comprising:

activating a first ventricle by delivering stimulation to at least one stimulation site;

estimating a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation of the first ventricle;

computing a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site of the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation;

activating the other ventricle by delivering stimulation to at least one stimulation site;

estimating a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation of the other ventricle;

computing a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation; and

determining a pacing therapy based on an activation time interval difference between the first and second activation time intervals, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.

2. The method of claim 1, wherein estimating comprises:

detecting at least one depolarization wave resulting from the stimulation of the first or other ventricle using at least one electrode positioned in a region in close vicinity to HIS bundle and the valve plane defined by an imaginary approximate half circle below the valve plane having a radius of about 10 mm, the half circle starting at the valve plane on right ventricle side, crossing septum below the valve plane, reaching the valve plane on left ventricle side and ending at the starting point on the right ventricle side; and

estimating the point in time for detection of the at least one depolarization wave as the point of time for arrival at the AV node.

3. The method of claim 1, wherein estimating comprises:

detecting at least one depolarization wave resulting from the stimulation of the first or other ventricle using at least one electrode positioned at distance of 0-20 mm from HIS bundle and below the valve plane; and

estimating the point in time for detection of the at least one depolarization wave as the point of time for arrival at the AV node.

4. The method of claim 3, further comprising:

detecting HIS potential at an electrode positioned close to the valve plane and septum;

determining an approximate location of HIS bundle to correspond to the position of the electrode detecting HIS potential; and

positioning at least one electrode within a region defined by imaginary approximate half circle-like line below the valve plane having a distance to the approximate location of HIS bundle of about 10 mm or at distance of 0-20 mm from HIS bundle and below the valve plane.

5. The method of claim 1, wherein estimating comprises:

detecting at least one depolarization wave resulting from the stimulation of the first or other ventricle using an electrode positioned in the orifice of coronary sinus or within a distance of about 20 mm from the orifice of coronary sinus and in coronary sinus; and

estimating the point in time for detection of the at least one depolarization wave as the point of time for arrival at the AV node.

6. The method of claim 5, further comprising:

detecting at least one retrograde depolarization wave resulting from the stimulation of the first or other ventricle using the electrode positioned in the orifice of coronary sinus or within a distance of about 20 mm from the orifice of coronary sinus and in coronary sinus;

estimating the point in time for detection of the at least one retrograde depolarization wave as the point of time for arrival at the AV node;

comparing the activation time interval difference between the first and second activation time intervals for the depolarization waves resulting from a stimulation of the first and other ventricle, respectively, with an activation time interval difference between the first and second activation time intervals for the retrograde depolarization waves corresponding to the same stimulation in the first and other ventricle; and

if the activation time intervals differences are substantially equal, determining that the activation time interval difference between the first and second activation time intervals for the depolarization waves was correctly determined.

7. The method according to claim 1, wherein estimating comprises:

detecting at least one retrograde depolarization wave resulting from the stimulation of the first or other ventricle using an electrode positioned in right or left atrium; and

estimating the point in time for detection of the at least one depolarization wave as the point of time for arrival at the AV node.

8. The method of claim 7, further comprising:

distinguishing a subsequent depolarization event due to retrograde conduction from a sinus node induced depolarization by;

detecting a P-wave interval of the sinus rhythm during a period prior to a determination of first and second activation time intervals; and

delivering the stimulation to the ventricles using a shorter interval than an P-wave interval of the detected sinus rhythm.

9. A system for determining cardiac pacing therapy of a patient in which an implantable cardiac stimulation device is adapted to be implanted, the system comprising:

a pacing module configured to provide pacing signals for delivery to the patient via medical leads including electrodes connectable to the pacing module, wherein at least one electrode is adapted to be positioned in each ventricle for activating respective ventricle by delivering stimulation to at least one stimulation site;

an estimating module configured to estimate a point of time for arrival at the AV node for at least one depolarization wave resulting from a stimulation in a ventricle;

an activation time interval computing module configured to compute activation time intervals substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site of a ventricle to the AV node using the estimated arrival of the depolarization wave and a point of time for delivery of stimulation; and

a ventricular pacing controlling module configured to determine a pacing therapy based on an activation time difference between the first and second activation time intervals, wherein the first activation time interval corresponds to the time required for at least one depolarization wave to travel from the stimulation site of the first ventricle to the AV node and the second activation time interval corresponds to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node, the pacing therapy comprising pacing the first ventricle prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and pacing the other ventricle prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.

10. The system of claim 9, further comprising:

at least one electrode adapted to be positioned in a region in close vicinity to HIS bundle and the valve plane defined by an imaginary approximate half circle below the valve plane having a radius of about 10 mm, the half circle starting at the valve plane on right ventricle side, crossing septum below the valve plane, reaching the valve plane on left ventricle side and ending at the starting point on the right ventricle side; and

wherein the detecting module is configured to detect at least one depolarization wave resulting from the stimulation of the first or other ventricle using the at least one electrode adapted to be positioned in the region in close vicinity to HIS bundle and the valve plane; and

wherein the estimating module is configured to use the point of time for detection of the at least one depolarization wave as the point of time for arrival at the AV node in the estimation.

11. The system of claim 9, further comprising:

at least one electrode adapted to be positioned at a distance between 0-20 mm from HIS bundle and below the valve plane; and

wherein the detecting module is configured to detect at least one depolarization wave resulting from the stimulation of the first or other ventricle using the at least one electrode adapted to be positioned in the region in close vicinity to HIS bundle and the valve plane; and

wherein the estimating module is configured to use the point of time for detection of the at least one depolarization wave as the point of time for arrival at the AV node in the estimation.

12. The system of claim 9, further comprising:

at least one electrode adapted to be positioned in the orifice of coronary sinus or within a distance of about 20 mm from the orifice of coronary sinus within coronary sinus; and

wherein the detection module is configured to detect at least one depolarization wave resulting from the stimulation of the first or other ventricle using the electrode adapted to be positioned in the orifice of coronary sinus or within a distance of about 20 mm from the orifice of coronary sinus within coronary sinus; and

wherein the estimation module is configured to use the point of time for detection of the at least one depolarization wave as the point of time for arrival at the AV node in the estimation.

13. The system of claim 12, wherein:

the detection module is configured to detect at least one retrograde depolarization wave resulting from the stimulation of the first or other ventricle using the electrode adapted to be positioned in the orifice of coronary sinus or within a distance of about 20 mm from the orifice of coronary sinus and in coronary sinus;

the estimation module is configured to estimate the point in time for detection of the at least one retrograde depolarization wave as the point of time for arrival at the AV node; and

the activation time interval computing module is configured to;

compare the activation time interval difference between the first and second activation time intervals for the depolarization waves resulting from a stimulation of the first and other ventricle, respectively, with an activation time interval difference between the first and second activation time intervals for the retrograde depolarization waves corresponding to the same stimulation in the first and other ventricle; and

determine that the activation time interval difference between the first and second activation time intervals for the depolarization waves are correct if the activation time intervals differences are substantially equal.

14. The system of claim 9, further comprising:

at least one electrode adapted to be positioned in left or right atrium; and

wherein the detection module is configured to detect at least one retrograde depolarization wave resulting from the stimulation of the first or other ventricle using the electrode adapted to be positioned in right or left atrium; and

wherein the estimating module is configured to use the point of time for detection of the at least one depolarization wave as the point of time for arrival at the AV node in the estimation.

15. The system of claim 14, wherein:

the detection module is configured to distinguish a subsequent depolarization event due to retrograde conduction from a sinus node induced depolarization by performing a detection of a P-wave interval of the sinus rhythm during a period prior to a determination of first and second activation time intervals; and

the pacing module is configured to deliver the stimulation to the ventricles using a shorter interval than an P-wave interval of the detected sinus rhythm.