Biosensors and methods for making and using them
First Claim
Patent Images
1. A composition comprising a porous matrix comprising a lattice of spherical particles having a surface coated with an immobilized enzyme, wherein:
- the porous matrix comprises a micro-porous metal that functions as an electrode in an electrochemical sensor, wherein the electrode consumes hydrogen peroxide in the electrochemical sensor;
the porous matrix is at least 10, 100, or 1000 microns thick; and
the composition is implantable within a mammal.
0 Assignments
0 Petitions
Accused Products
Abstract
Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
-
Citations
16 Claims
-
1. A composition comprising a porous matrix comprising a lattice of spherical particles having a surface coated with an immobilized enzyme, wherein:
-
the porous matrix comprises a micro-porous metal that functions as an electrode in an electrochemical sensor, wherein the electrode consumes hydrogen peroxide in the electrochemical sensor; the porous matrix is at least 10, 100, or 1000 microns thick; and the composition is implantable within a mammal. - View Dependent Claims (2, 3, 4, 5)
-
-
6. An analyte sensor apparatus for implantation within a mammal, the analyte sensor apparatus comprising a porous matrix comprising a lattice of
spherical particles having a surface coated with an immobilized enzyme, wherein: -
the porous matrix comprises a micro-porous metal; the porous matrix is at least 1 micron in thickness; the immobilized enzyme is coated with an analyte modulating layer comprising a siloxane; and the porous matrix functions as a working electrode in the analyte sensor apparatus, and wherein the electrode consumes hydrogen peroxide in the analyte sensor. - View Dependent Claims (7, 8, 9, 10, 11, 12)
-
-
13. A glucose sensor apparatus for implantation within a mammal, the apparatus comprising:
-
a counter electrode; a reference electrode; a working electrode comprising a porous matrix including a lattice of spherical micro-porous metal particles; an analyte sensing layer comprising glucose oxidase coating the spherical micro-porous metal particles; an analyte modulating layer coating the analyte sensing layer; a protein layer comprising an albumin; and an adhesion promoting layer disposed on the analyte sensing layer, wherein the adhesion promoting layer promotes the adhesion between the analyte sensing layer and an analyte modulating layer disposed on the analyte sensing layer, and wherein the electrode consumes hydrogen peroxide in the analyte sensor. - View Dependent Claims (14, 15, 16)
-
Specification