Slope-based compensation including secondary output signals
First Claim
1. A method for determining an analyte concentration in a biological sample using a biosensor system comprising a sample interface having a working electrode and a counter electrode, a processor, and a signal generator connected to the processor, comprising:
- generating by the processor, a command to direct the signal generator to provide an electrical input signal;
applying the electrical input signal provided by the signal generator to the biological sample through the working electrode and the counter electrode of the sample interface,generating from the electrical input signal at least one output signal in response to a redox reaction of an analyte from the biological sample;
generating using the processor a second command to direct the signal generator to provide a second electrical input signal;
applying the second electrical input signal to the biological sample through an electrochemical or optical sensor system;
in response to the second command, generating multiple secondary output signals using the electrochemical or optical sensor system from the biological sample independently from the at least one output signal and redox reaction of the analyte from the biological sample;
determining by the processor at least one index function responsive to at least one error parameter from the at least one output signal and at least two error parameters from the multiple secondary output signals; and
determining by the processor, the analyte concentration in the biological sample from the at least one output signal and a slope compensation equation responsive to the at least one index function, where the slope compensation equation includes at least one reference correlation and at least one slope deviation,where the at least one index function represents the influence of the error parameters on the slope deviation, andwhere the at least one index function is responsive to at least one of a slope deviation of the error parameters and an intercept deviation of error parameters.
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Abstract
A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.
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Citations
29 Claims
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1. A method for determining an analyte concentration in a biological sample using a biosensor system comprising a sample interface having a working electrode and a counter electrode, a processor, and a signal generator connected to the processor, comprising:
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generating by the processor, a command to direct the signal generator to provide an electrical input signal; applying the electrical input signal provided by the signal generator to the biological sample through the working electrode and the counter electrode of the sample interface, generating from the electrical input signal at least one output signal in response to a redox reaction of an analyte from the biological sample; generating using the processor a second command to direct the signal generator to provide a second electrical input signal; applying the second electrical input signal to the biological sample through an electrochemical or optical sensor system; in response to the second command, generating multiple secondary output signals using the electrochemical or optical sensor system from the biological sample independently from the at least one output signal and redox reaction of the analyte from the biological sample; determining by the processor at least one index function responsive to at least one error parameter from the at least one output signal and at least two error parameters from the multiple secondary output signals; and determining by the processor, the analyte concentration in the biological sample from the at least one output signal and a slope compensation equation responsive to the at least one index function, where the slope compensation equation includes at least one reference correlation and at least one slope deviation, where the at least one index function represents the influence of the error parameters on the slope deviation, and where the at least one index function is responsive to at least one of a slope deviation of the error parameters and an intercept deviation of error parameters. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for determining an analyte concentration in a biological sample using a biosensor system comprising a sample interface having a working electrode and a counter electrode, a processor, and a signal generator connected to the processor, the method comprising:
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generating by the processor, a command to direct the signal generator to provide an electrical input signal; applying the electrical input signal provided by the signal generator to the biological sample through the counter electrode and the working electrode of the sample interface, generating from the electrical input signal, at least one analytic output signal in response to a redox reaction of an analyte from the biological sample; generating using the processor a second command to direct the signal generator to provide a second electrical input signal; generating a first secondary output signal from the biological sample in response to the second command; generating a second secondary output signal in response to the second command; determining by the processor at least one index function responsive to at least one error parameter from the first secondary output signal and one error parameter responsive to at least one error parameter from the second secondary output signal; adjusting a correlation for determining the analyte concentration in the biological sample from the at least one analytic output signal with a slope compensation equation responsive to the at least one index function, where the slope compensation equation includes at least one reference correlation and at least one slope deviation; and determining the analyte concentration in the biological sample from the at least one analytic output signal and the correlation, where the at least one index function represents the influence of the error parameters on the slope deviation, and where the at least one index function is responsive to at least one of a slope deviation of the error parameters or an intercept deviation of the error parameters. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification