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Detection of intraamniotic infection

  • US 9,164,092 B2
  • Filed: 02/07/2014
  • Issued: 10/20/2015
  • Est. Priority Date: 11/25/2009
  • Status: Active Grant
First Claim
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1. A method for the diagnosis of intra-amniotic inflammation or infection in a pregnant female mammalian subject comprising:

  • (a) measuring in a sample of cervical-vaginal fluid obtained from said subject the levels of interleukin-6 (IL-6) and fetal fibronectin (fFN) relative to the corresponding levels of said proteins in normal cervical-vaginal fluid or cervical-vaginal fluid known to be indicative of intra-amniotic inflammation or infection; and

    (b) diagnosing said subject with intra-amniotic inflammation or infection if each of said levels of each of said proteins in said sample is determined to show a statistically significant difference relative to the corresponding levels of each of said proteins in said normal cervical-vaginal fluid, or is determined not to show a statistically significant difference relative to the corresponding levels of each of said proteins in said cervical-vaginal fluid known to be indicative of intra-amniotic inflammation or infection.

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