Supply unit for continuous loading

• US 9,164,114 B2
• Filed: 02/16/2012
• Issued: 10/20/2015
• Est. Priority Date: 04/19/2011
• Status: Active Grant

• Current Assignee: Roche Molecular Systems Inc (Roche Holding AG)
• Original Assignee: Roche Molecular Systems Inc (Roche Holding AG)
• Inventors: Baumann, Renato, Kaeppeli, Marcel, Rinderknecht, Markus, Wassermann, Johann Florian
• Primary Examiner(s): Nagpaul, Jyoti
• Application Number:
  US13/397,877
• Publication Number:
  US 20120269604A1
• Time in Patent Office: 1,342 Days
• US Class Current: 1/1
• CPC Class Codes: G01N 2035/00089 Magazines
• CPC Class Codes: G01N 2035/00306 Housings, cabinets, control panels (details)
• CPC Class Codes: G01N 2035/0425 Stacks, magazines or elevators for plates
• CPC Class Codes: G01N 2035/0498 Drawers used as storage or dispensing means for vessels or cuvettes
• CPC Class Codes: G01N 35/04 Details of the conveyor system G01N35/021 - G01N35/028 take precedence

Abstract

The present invention relates to a system and method for continuous loading of consumables into an analyzer comprising a stacker unit which can be uncoupled from the transport system for transporting the consumables from the stacker to the analytical modules and within and/or between the analytical modules.

Claims

1. A system for continuous loading of consumables into an analyzer wherein said analyzer comprises:

at least one separation station for isolating nucleic acids;

at least one amplification station for amplifying nucleic acids;

a transport system for automatically transporting said consumables within the analyzer, wherein said transport system comprises a first handler and a second handler, wherein said first handler and said second handler comprise gripper fingers for gripping said consumables;

a stacker unit comprising at least one stacker for holding consumables, wherein said stacker unit is integrated into the analyzer, and wherein said stacker unit is capable of being decoupled from said analyzer for manual or automated loading of said consumables, wherein said stacker unit is in a locked position within said analyzer when access to the consumables in the at least one stacker is required by said first handler for transporting consumables from said stacker unit to an intermediate station, and said stacker unit is in an unlocked position when access to the consumables in the stacker is not required by said first handler, wherein at said unlocked position, opening of said stacker unit and loading of consumables can occur while said second handler is used for transporting consumables between said intermediate station and said at least one separation station or while said first handler is used for transporting consumables to said at least one amplification station;

wherein the stacker unit has a first end position within the analyzer and a second end position outside of the analyzer, and wherein, in the second end position, the at least one stacker comprised in the stacker unit is accessible for loading of consumables into the stacker, and the stacker unit is locked when in the second end position;

and a computer controller that controls a mechanism for unlocking said stacker unit and for locking said stacker unit in the first end position or in the second end position.

2. The system according to claim 1, wherein said system comprises an automated mechanism for automatically sliding the open stacker unit into the first end position within the analyzer before locking the stacker unit in its locked position inside the analyzer.

3. The system according to claim 1, wherein the stacker unit is a drawer, and said decoupling comprises opening of the drawer for loading of consumables when the stacker unit is unlocked.

4. The system according to claim 1, wherein the opening and closing of the stacker unit is completely automated.

5. The system according to claim 1, further comprising more than two different types of consumables, wherein any one stacker is constructed and arranged to receive one specific type of consumables.

6. The system according to claim 5, wherein each one type of said more than two different types of consumables comprises a unique surface geometry.

7. The system according to claim 1, wherein said stacker unit is a pivotable unit.

8. The system according to claim 1, wherein said consumables are hardware-coded.

9. The system according to claim 1, wherein access to the stacker unit for loading and/or unloading consumables is guided via a display.

10. The system according to claim 1, wherein said consumables are loaded into the stacker while nucleic acids are isolated in the at least one separation station and/or nucleic acids are amplified in the at least one amplification station.

11. A method of continuous loading of consumables into an analyzer, comprising the steps of:

uncoupling a stacker unit comprising at least one stacker for receiving said consumables from a transport system comprising a first and a second handler wherein said first handler comprises gripper fingers for gripping said consumables and transports said consumables from said at least one stacker to an intermediate station within said analyzer, wherein said stacker unit is integrally mounted within the housing of said analyzer,

sliding said stacker unit to an open position,

locking said stacker unit in said open position,

loading consumables into said at least one stacker comprised in said stacker unit either while a second handler that comprises gripper fingers for gripping said consumables transports said consumables from said intermediate station to at least one separation station for isolating nucleic acids or while said first handler transports consumables to at least one amplification station for amplifying nucleic acid, or while an analytical process is performed within said analyzer,

unlocking said stacker unit when consumables are fully loaded into the stacker unit,

closing said stacker unit, wherein said stacker unit is locked in its closed position to be operatively coupled to said transport system;

wherein the steps of locking said stacker unit and unlocking said stacker unit are controlled by a computer controller.

12. The method of claim 11, wherein, when closing the stacker unit, the stacker unit automatically slides into a first end position within the analyzer.

13. The method of claim 12, wherein the sliding of the stacker unit between the first end position and a second end positions outside of the analyzer is fully automated.

14. The method of claim 13, further comprising as a first step:

displaying on a display time windows for a user to load or unload consumables into the stacker unit.

15. The method of claim 12, further comprising as a first step:

displaying on a display time windows for a user to load or unload consumables into the stacker unit.

16. The method of claim 11, further comprising as a first step:

displaying on a display time windows for a user to load or unload consumables into the stacker unit.

17. The method of claim 11, wherein more than two different types of consumables are loaded into the analyzer wherein any one stacker is constructed and arranged to receive one specific type of consumables.

18. The method of claim 17, wherein each one type of said more than two different types of consumables comprises a unique surface geometry.