Intra-burst pulse variation for stimulation therapy

• US 9,168,374 B2
• Filed: 01/25/2012
• Issued: 10/27/2015
• Est. Priority Date: 01/28/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Su, Xin
• Primary Examiner(s): Gedeon, Brian T
• Application Number:
  US13/358,038
• Publication Number:
  US 20120197336A1
• Time in Patent Office: 1,371 Days
• Field of Search: 607/2, 607/9, 607/11, 607/12, 607/15, 607/39, 607/40, 607/46, 607/48
• US Class Current: 1/1
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36107 Sexual dysfunction stimulating genital organs A61N1/36007
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters

Abstract

In general, the disclosure is directed to devices, systems, and techniques for delivering electrical stimulation to a patient with varying pulse frequencies within each burst of pulses. The pulse frequency variation within each burst of pulses may be between approximately 20 Hz and 40 Hz. In some examples, the pulse frequency may be increased, decreased, or polynomially varied within each burst. In other examples, the frequency of intrinsic nerve impulses may be detected and used to deliver pulses with the detected frequency or an inverse of the detected frequency. Electrical stimulation therapy with intra-burst pulse frequency variation may alleviate bladder dysfunction, bowel dysfunction, pain or other disorders.

Claims

1. A method comprising:

delivering electrical stimulation therapy to a patient, wherein the electrical stimulation therapy comprises a plurality of bursts and a plurality of pulses within each burst of the plurality of bursts; and

varying, by a control module and within each burst of the plurality of bursts, a pulse frequency of the respective plurality of pulses within each burst of the plurality of bursts, wherein the pulse frequency is varied between approximately 20 Hz and 40 Hz.

2. The method of claim 1, wherein varying the pulse frequency comprises controlling the pulse frequency to vary by one of increasing, without decreasing, the pulse frequency within each burst of the plurality of bursts or decreasing, without increasing, the pulse frequency within each burst of the plurality of bursts.

3. The method of claim 2, wherein varying the pulse frequency within each burst comprises controlling the pulse frequency to vary by at least one of linearly varying the pulse frequency within each burst, exponentially varying the pulse frequency within each burst, or polynomially varying the pulse frequency within each burst.

4. The method of claim 1, wherein varying the pulse frequency comprises randomly varying the pulse frequency within each burst of the plurality of bursts.

5. The method of claim 1, wherein a burst frequency of the plurality of bursts is between approximately 1 Hz and 10 Hz.

6. The method of claim 1, further comprising varying, within each burst of the plurality of bursts, at least one of a current amplitude or a voltage amplitude of the respective plurality of pulses within each burst of the plurality of bursts.

7. The method of claim 1, further comprising detecting a physiological state of the patient, wherein varying the pulse frequency within each burst comprises one of increasing the pulse frequency within each burst, decreasing the pulse frequency within each burst, or randomly changing the pulse frequency within each burst based on the detection.

8. The method of claim 1, further comprising detecting a frequency variation of intrinsic nerve impulses, wherein varying the pulse frequency of the respective plurality of pulses within each burst comprises varying the pulse frequency within each burst according to one of the detected frequency variation or an inverse of the detected frequency variation.

9. The method of claim 1, wherein the electrical stimulation therapy is configured to treat at least one of bladder dysfunction or colorectal dysfunction.

10. The system of claim 1, wherein the electrical stimulation therapy is configured to treat at least one of bladder dysfunction or colorectal dysfunction.

11. The system of claim 1, wherein the control module and therapy delivery module are both housed within an implantable medical device.

12. The system of claim 1, wherein the therapy delivery module is housed within an implantable medical device, and wherein the control module is housed within an external programmer.

13. The method of claim 1, wherein delivering electrical stimulation therapy to the patient comprises delivering the electrical stimulation therapy at the varied pulse frequency to one or more spinal nerves of the patient.

14. The method of claim 1, wherein delivering electrical stimulation therapy to the patient comprises delivering the electrical stimulation therapy at the varied pulse frequency to one or more sacral nerves of the patient.

15. The method of claim 1, wherein varying the pulse frequency of the respective plurality of pulses within each burst comprises varying the pulse frequency to capture at least one of a plurality of different nerve fibers or a plurality of different muscle fibers within each burst of pulses.

16. The method of claim 1, further comprising detecting a frequency variation of intrinsic nerve impulses, wherein varying the pulse frequency of the respective plurality of pulses within each burst comprises varying the pulse frequency within each burst according to an inverse of the detected frequency variation.

17. The method of claim 1, wherein one or more parameters of the electrical stimulation therapy are selected to decrease a frequency of bladder contractions.

18. A system comprising:

a therapy delivery module configured to generate and deliver electrical stimulation therapy to a patient, wherein the electrical stimulation therapy comprises a plurality of bursts and a plurality of pulses within each burst of the plurality of bursts; and

a control module configured to vary, within each burst of the plurality of bursts, a pulse frequency of the respective plurality of pulses within each burst of the plurality of bursts, wherein the pulse frequency is varied between approximately 20 Hz and 40 Hz.

19. The system of claim 18, wherein the control module is configured to vary the pulse frequency by increasing, without decreasing, the pulse frequency within each burst of the plurality of bursts or decreasing, without increasing, the pulse frequency within each burst of the plurality of bursts.

20. The system of claim 19, wherein the control module is configured to vary the pulse frequency by at least one of linearly varying the pulse frequency within each burst, exponentially varying the pulse frequency within each burst, or polynomially varying the pulse frequency within each burst.

21. The system of claim 18, wherein the control module is configured to randomly vary the pulse frequency within each burst of the plurality of bursts.

22. The system of claim 18, wherein a burst frequency of the plurality of bursts is between approximately 1 Hz and 10 Hz.

23. The system of claim 18, wherein the control module is configured to vary, within each burst of the plurality of bursts, at least one of a current amplitude or a voltage amplitude of the respective plurality of pulses within each burst of the plurality of bursts.

24. The system of claim 18, further comprising a sensor configured to detect a physiological state of the patient, wherein the control module is configured to one of increase the pulse frequency within each burst, decrease the pulse frequency within each burst, or randomly vary the pulse frequency within each burst based on the detection.

25. The system of claim 18, further comprising an impulse sensing module configured to detect a frequency variation of intrinsic nerve impulses, wherein the control module is configured to vary the pulse frequency within each burst according to one of the detected frequency variation or an inverse of the detected frequency variation.

26. A system comprising:

means for delivering electrical stimulation therapy to a patient, wherein the electrical stimulation therapy comprises a plurality of bursts and a plurality of pulses within each burst of the plurality of bursts; and

means for varying, within each burst of the plurality of bursts, a pulse frequency of the respective plurality of pulses within each burst of the plurality of bursts, wherein the pulse frequency is varied between approximately 20 Hz and 40 Hz.

27. The system of claim 26, wherein the means for varying the pulse frequency at least one of linearly varies the pulse frequency within each burst, exponentially varies the pulse frequency within each burst, or polynomially varies the pulse frequency within each burst.

28. The system of claim 26, further comprising means for detecting a physiological state of the patient, wherein the means for varying the pulse frequency one of increases the pulse frequency within each burst, decreases the pulse frequency within each burst, or randomly varies the pulse frequency within each burst based on the detection.

29. The system of claim 26, further comprising means for detecting a frequency variation of intrinsic nerve impulses, wherein the means for varying the pulse frequency varies the pulse frequency within each burst according to one of the detected frequency variation or an inverse of the detected frequency variation.