System and method for triggered pacing

• US 9,168,380 B1
• Filed: 07/24/2014
• Issued: 10/27/2015
• Est. Priority Date: 07/24/2014
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Greenhut, Saul E, Carney, James K
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US14/340,248
• Time in Patent Office: 460 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

A medical device system including an intracardiac pacemaker is configured to receive by an implantable medical device sensing module a first cardiac signal using a first pair of electrodes implanted outside the cardiovascular system and identify a P-wave from the first cardiac signal. The system transmits a wireless trigger signal to the intracardiac pacemaker in response to identifying the P-wave. The intracardiac pacemaker delivers a pacing therapy in response to the trigger signal.

Claims

1. A method for controlling automated delivery of therapeutic stimulation pulses by a medical device system including an intracardiac pacemaker implanted in a patient, the method comprising:

acquiring by an implantable medical device sensing module a first cardiac signal using a first pair of electrodes selected from a plurality of available electrode pairs that are implanted outside the cardiovascular system, the plurality of available electrodes defining at least one sensing vector that is approximately parallel with a cranial-caudal axis of the patient;

generating a first electrocardiogram (ECG) signal from the received first cardiac signal;

identifying a P-wave from the ECG signal;

transmitting a wireless trigger signal from the implantable medical device to the intracardiac pacemaker in response to identifying the P-wave; and

delivering a pacing therapy by the pacemaker in response to the trigger signal.

2. The method of claim 1, further comprising identifying the P-wave in response to at least one of an amplitude, a frequency content, a number of peaks, a signal width, and a morphology waveform of the ECG signal, wherein the first pair of electrodes defines the at least a first sensing vector that is approximately parallel with the cranial caudal axis.

3. The method of claim 1, further comprising:

acquiring by the sensing module a second cardiac signal using a second pair of electrodes selected from the plurality of electrodes, the second pair of electrodes defining at least a first sensing vector more closely aligned with a transverse plane of the patient than the first pair of electrodes, wherein the first pair of electrodes defines the first sensing vector that is approximately parallel with the cranial caudal axis;

generating a second ECG signal from the received second cardiac signal; and

identifying the P-wave from the first ECG by using the second ECG to reject non-P-wave events in the first ECG.

4. The method of claim 3, further comprising:

applying a first sensing threshold to the first ECG;

sensing first events from the first ECG in response to first ECG crossings of the first sensing threshold;

applying a second sensing threshold to the second ECG;

sensing second events from the second ECG in response to second ECG crossings of the second threshold;

identifying first events that are sensed simultaneously with second events; and

identifying the P-wave from the first ECG by rejecting the first events that are sensed simultaneously with second events.

5. The method of claim 3, further comprising:

setting a sensing window applied to the first ECG; and

identifying the P-wave during the sensing window in response to the first ECG crossing a first threshold,

wherein setting the sensing window comprises;

applying a second threshold to the second ECG,

identifying a ventricular event from the second ECG signal in response to the second ECG crossing the second threshold,

setting the sensing window at a time interval after the identified ventricular event.

6. The method of claim 1, further comprising:

passing a P-wave sense signal to a tachyarrhythmia detector of the implantable medical device in response to identifying the P-wave;

detecting a tachycardia in response to the P-wave sense signal;

controlling the trigger signal in response to detecting the tachycardia.

7. The method of claim 1, further comprising:

passing P-wave sense signals to a tachyarrhythmia detector of the implantable medical device in response to identifying P-waves from the first ECG;

detecting atrial fibrillation in response to a disappearance of the P-wave sense signal; and

controlling the trigger signal in response to detecting atrial fibrillation.

8. The method of claim 1, further comprising:

determining a P-wave amplitude from each of a plurality of sensing vectors of the plurality of available electrode pairs;

comparing the P-wave amplitudes; and

selecting the first pair of electrodes from the plurality of electrode pairs in response to a highest P-wave amplitude.

9. The method of claim 8, further comprising:

identifying P-waves from an ECG signal generated by the sensing module using a previously selected pair of electrodes;

transmitting wireless trigger signals in response to identifying the P-waves using the previously selected pair of electrodes; and

wherein comparing the P-wave amplitudes and selecting the first pair of electrodes is performed during the identifying P-waves from the previously generated ECG signal.

10. The method of claim 1, wherein identifying the P-wave comprises:

sensing a plurality of events based on threshold crossings of the first ECG signal;

sensing an R-wave from a second pair of electrodes having at least one electrode that is different from the electrodes in the first pair of electrodes;

setting a P-wave sensing window in response to the sensed R-wave;

sensing a T-wave from one of the second pair of electrodes and a third pair of electrodes;

rejecting ones of the plurality of sensed events that occur outside the P-wave sensing window;

rejecting ones of the plurality of sensed events that occur simultaneously with the sensed R-wave or the sensed T-wave;

passing a P-wave sense signal to a trigger signal controller in response to a non-rejected one of the plurality of events; and

controlling the trigger signal emitting device to emit the wireless trigger signal in response to the trigger signal controller acquiring the P-wave sense signal.

11. An implantable medical device system, comprising:

a first device comprising a sensing module coupled to a plurality of electrodes implanted outside the cardiovascular system of a patient and configured to;

receive by the sensing module a first cardiac signal using a first pair of electrodes of the plurality of electrodes, the plurality of electrodes defining at least a first sensing vector that is approximately parallel with a cranial-caudal axis of the patient;

generate a first electrocardiogram (ECG) signal based on the first cardiac signal;

identify a P-wave using the first ECG signal;

a trigger signal emitting device controlled by the first device to emit a wireless trigger signal in response to the identified P-wave; and

an intracardiac pacemaker configured to detect the wireless trigger signal and deliver a pacing therapy in response to the wireless trigger signal.

12. The device of claim 11, wherein the first device is configured to identify the P-wave in response to at least one of an amplitude, a frequency content, a number of peaks, a signal width, and a morphology waveform of the first ECG signal, wherein the first pair of electrodes defines the first sensing vector that is approximately parallel with the cranial caudal axis.

13. The device of claim 11, wherein the first device is further configured to:

receive by the sensing module a second cardiac signal using a second pair of electrodes of the plurality of electrodes, the second pair of electrodes defining a second sensing vector more closely aligned with a transverse plane of the patient than the first sensing vector, wherein the first pair of electrodes defines the first sensing vector that is approximately parallel with the cranial caudal axis;

generate a second ECG signal based on the second cardiac signal; and

identify the P-wave from the first ECG signal by using the second ECG signal to reject non-P-wave events in the first ECG signal.

14. The device of claim 13, wherein the first device is further configured to:

apply a first sensing threshold to the first ECG signal;

sense first events from the first ECG signal in response to first ECG signal crossings of the first sensing threshold;

apply a second sensing threshold to the second ECG signal;

sense second events from the second ECG signal in response to second ECG signal crossings of the second threshold;

identify first events that are sensed simultaneously with second events; and

identify the P-wave from the first ECG signal by rejecting the first events that are sensed simultaneously with second events.

15. The device of claim 13, wherein the first device is further configured to:

set a sensing window applied to the first ECG signal; and

identify the P-wave during the sensing window in response to the first ECG signal crossing a first threshold,

wherein setting the sensing window comprises;

applying a second threshold to the second ECG signal,

identifying a ventricular event from the second ECG signal in response to the second ECG signal crossing the second threshold,

setting the sensing window at a time interval after the identified ventricular event.

16. The device of claim 13, further comprising:

a tachyarrhythmia detector acquiring a P-wave sense signal in response to identifying the P-wave;

the tachyarrhythmia detector configured to detect a tachycardia in response to the P-wave sense signal;

the first device further configured to control the trigger signal emitting device in response to detecting the tachycardia.

17. The device of claim 11, further comprising:

a tachyarrhythmia detector configured to receive P-wave sense signals in response to P-waves identified from the first ECG signal and detect atrial fibrillation in response to a disappearance of the P-wave sense signal,

wherein the first device is further configured to control the trigger signal emitting device in response to detecting the atrial fibrillation.

18. The device of claim 11, wherein the first device is further configured to:

determine a P-wave amplitude from each of a plurality of sensing vectors of the plurality of available electrode pairs;

compare the P-wave amplitudes; and

select the first pair of electrodes from the plurality of electrode pairs in response to a highest P-wave amplitude.

19. The device of claim 18, wherein the first device is further configured to:

identify P-waves from an ECG signal received by the sensing module using a previously selected pair of electrodes;

control the trigger signal emitting device to transmit wireless trigger signals in response to identifying the P-waves using the previously selected pair of electrodes;

wherein comparing the P-wave amplitudes and selecting the first pair of electrodes is performed during the identifying P-waves from the previously selected ECG signal.

20. The device of claim 11, wherein identifying the P-wave comprises:

sensing a plurality of events based on threshold crossings of the first ECG signal;

sensing an R-wave from a second sensing vector;

setting a P-wave sensing window in response to the sensed R-wave;

sensing a T-wave from one of the second sensing vector and a third sensing vector;

rejecting ones of the plurality of sensed events that occur outside the P-wave sensing window; and

rejecting ones of the plurality of sensed events that occur simultaneously with the sensed R-wave or the sensed T-wave;

the first device further comprising a trigger signal controller, the first device configured to pass a P-wave sense signal to the trigger signal controller in response to a non-rejected one of the plurality of events, the trigger signal controller configured to control the trigger signal emitting device to emit the wireless trigger signal in response to acquiring the P-wave sense signal.

21. A non-transitory, computer-readable storage medium storing a set of instructions that cause an implantable medical device system including an intracardiac pacemaker to perform a method, the method comprising:

acquiring by an implantable medical device sensing module a first cardiac signal using a first pair of electrodes of a plurality of available electrode pairs that are implanted outside the cardiovascular system, the first pair of electrodes defining a sensing vector that is approximately parallel to a cranial-caudal axis of the patient;

generating a first electrocardiogram (ECG) signal based on the first cardiac signal;

identifying a P-wave from the first ECG signal;

transmitting a wireless trigger signal from an emitting device to the intracardiac pacemaker in response to identifying the P-wave; and

delivering a pacing therapy by the pacemaker in response to the trigger signal.