Charged particle cancer therapy system X-ray apparatus and method of use thereof

• US 9,168,392 B1
• Filed: 05/12/2014
• Issued: 10/27/2015
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Primary Examiner(s): NGUYEN, KIET TUAN
• Application Number:
  US14/275,481
• Time in Patent Office: 533 Days
• Field of Search: 250/492.3
• US Class Current: 1/1
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1097 Means for immobilizing the patient
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: A61N 5/1081 Rotating beam systems with a specific mechanical construction, e.g. gantries
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: G21K 1/093 by magnetic means
• CPC Class Codes: G21K 5/04 with beam-forming means
• CPC Class Codes: H01J 35/045 Electrodes for controlling the current of the cathode ray, e.g. control grids
• CPC Class Codes: H01J 37/08 Ion sources; Ion guns
• CPC Class Codes: H01J 37/1475 magnetic
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 2007/002 for modifying beam trajectory, e.g. gantries
• CPC Class Codes: H05H 2007/048 for modifying beam trajectory, e.g. gantry systems
• CPC Class Codes: H05H 9/00 Linear accelerators

Abstract

An imaging system apparatus and method of use thereof is described in combination with a co-movable charged particle beamline apparatus element, such as one or more elements held and dynamically positioned by a gantry, where the method and apparatus are optionally elements of a positively charged particle cancer therapy system. In one embodiment, an X-ray imaging element is rigidly and semi-permanently attached to and co-moved with a proton directing element. For example, as the gantry relocates one or more elements of a proton beamline arc, the X-ray beam is mechanically forced to co-relocate with the proton directing element and/or the final proton beam path.

Claims

1. An apparatus for maintaining alignment of:

(1) a tumor imaging beam, traveling along a tumor imaging beam path, with (2) a tumor treatment beam, traveling along a tumor treatment beam path, the tumor treatment beam comprising positively charged particles for treatment of a tumor of a patient, the apparatus comprising;

a charged particle delivery system, comprising;

a movable magnet configured to guide the positively charged particles in said tumor treatment beam path to the tumor;

an imaging system, comprising;

an imaging source element, said imaging source element configured to deliver the tumor imaging beam along said tumor imaging beam path during use;

a rigid mechanical link linking said imaging source element to said movable magnet; and

means for co-moving said imaging source element and said movable magnet using said rigid mechanical link.

2. The apparatus of claim 1, said charged particle delivery system further comprising:

a gantry, said movable magnet supported by said gantry, said gantry configured to move said movable magnet during use; and

a beamline from an accelerator, said beamline including said movable magnet,

said tumor imaging beam path traversing through an aperture in said movable magnet.

3. The apparatus of claim 2, wherein said imaging beam path longitudinally overlaps said tumor treatment beam path in said movable magnet.

4. The apparatus of claim 3, further comprising:

means for rotating said movable magnet, wherein said rigid mechanical link, said imaging source element, and said movable magnet co-rotate with rotation of said movable magnet.

5. The apparatus of claim 4, said movable magnet comprising a terminal magnet of said beamline, said tumor treatment beam path passing through at least three magnets in said beamline.

6. The apparatus of claim 5, said movable magnet comprising:

a core; and

a coil coiled around said core,

wherein said tumor imaging beam path passes through at least one of said core and said coil.

7. The apparatus of claim 5, said imaging source element comprising at least one of:

an X-ray source element; and

an X-ray source housing element.

8. The apparatus of claim 7, further comprising:

a two-dimensional array of digital X-ray detectors, said two-dimensional array of digital X-ray detectors positioned in said tumor imaging beam path after said movable magnet.

9. The apparatus of claim 1, wherein said tumor treatment beam path longitudinally overlaps said imaging beam path in said moveable magnet.

10. A method for maintaining alignment of:

(1) a tumor imaging beam, traveling through a tumor imaging beam path, with (2) a tumor treatment beam, traveling through a tumor treatment beam path, the tumor treatment beam comprising positively charged particles for treatment of a tumor of a patient, the method comprising the steps of;

a movable magnet, of a charged particle delivery system, guiding the positively charged particles to the tumor along said tumor treatment beam path;

delivering the tumor imaging beam, from an imaging source element of an imaging system, along said tumor imaging beam path;

mechanically linking said imaging source element to said movable magnet with a rigid mechanical link; and

co-moving said imaging source element, said movable magnet, and said rigid mechanical link.

11. The method of claim 10, further comprising the steps of:

moving said moveable magnet to alter course of the positively charged particles; and

passing electromagnetic radiation from said imaging source element through an aperture in said movable magnet.

12. The method of claim 11, further comprising the step of:

simultaneously delivering, to the tumor, through said movable magnet;

(1) the positively charged particles and (2) the electromagnetic radiation.

13. The method of claim 12, further comprising the step of:

within said movable magnet, longitudinally overlapping the positively charged particles, from a synchrotron, with X-rays, from said imaging source element.

14. The method of claim 11, further comprising the steps of:

co-rotating said movable magnet and the patient through at least one hundred eighty degrees; and

delivering the positively charged particles along a downward and outward vector relative to a vertical axis passing through said movable magnet, said downward and outward vector rotating though at least one hundred eighty degrees during said step of co-rotating.

15. The method of claim 10, further comprising the step of:

while imaging an outer surface area of the tumor using electromagnetic radiation from the imaging source element, sealing the outer surface area of the tumor with the positively charged particles from a synchrotron.

16. The method of claim 10, further comprising the steps of:

positioning a two-dimensional array of digital X-ray detectors opposite the tumor from said imaging source element; and

using said two-dimensional array of digital X-ray detectors to image the tumor using X-rays from said imaging source element.

17. The method of claim 16, further comprising the step of:

co-rotating said moveable magnet and said two-dimensional array of digital X-ray detectors.

18. The method of claim 10, further comprising a step of:

radially transecting, in the tumor, the positively charged particle beam path with X-rays, from said imaging source element.

19. The method of claim 10, further comprising the step of:

scanning a vertical slice of the tumor, said step of scanning a vertical slice comprising the steps of;

varying current delivered to a coil proximate a gap in said movable magnet; and

varying energy of the positively charged particles delivered from a synchrotron; and

repeating said step of scanning a vertical slice of the tumor through at least one hundred eighty degrees of rotation of said moveable magnet.

20. The method of claim 10, further comprising the step of:

simultaneously collecting;

(1) X-ray images using said imaging source element and (2) tomographic images using the positively charged particles from a synchrotron.

21. The method of claim 20, further comprising the step of:

forming a composite image using said X-ray images and said tomographic images.