Systems and methods for the identification of compounds in medical fluids using admittance spectroscopy

• US 9,173,600 B2
• Filed: 06/08/2010
• Issued: 11/03/2015
• Est. Priority Date: 03/09/2009
• Status: Active Grant

• Current Assignee: James W. Bennett, Leonid Matsiev
• Original Assignee: S.E.A. Medical Systems Inc.
• Inventors: Matsiev, Leonid, Bennett, James W., Weickert, Michael J.
• Primary Examiner(s): Menon, Krishnan S
• Assistant Examiner(s): Gerido, Dwan A
• Application Number:
  US12/796,567
• Publication Number:
  US 20100305499A1
• Time in Patent Office: 1,974 Days
• Field of Search: 436/150, 436/149, 436/151, 73/530.1, 73/530.6, 604/67, 604/65, 324/693
• US Class Current: 1/1
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: G01N 27/026 Dielectric impedance spectroscopy electrochemical impedance spectroscopy for measuring corrosion G01N17/02

Abstract

Described herein are devices, systems, and methods for determining the composition of fluids, and particularly for describing the identity and concentration of one or more components of a medical fluid such as intravenous fluid. These devices, systems and methods take multiple complex admittance measurements from a fluid sample in order to identify the identity and the concentration of components of the fluid. The identity and concentration of all of the components of the solution may be simultaneously and rapidly determined. In some variations, additional measurement or sensing modalities may be used in addition to admittance spectroscopy, including optical, thermal, chemical, etc.

Claims

1. A system for determining the identity, concentration or identity and concentration of an intravenous drug solution by admittance spectroscopy to determine surface interactions of the intravenous drug solution on fluid-contacting surfaces of a plurality of pairs of electrodes, the system comprising:

a sensor comprising a plurality of pairs of electrodes having fluid-contacting surfaces, wherein each pair of electrodes is configured to have different surface interactions with the solution at different frequencies than the other pairs of electrodes;

a signal generator configured to provide current at a plurality of frequencies for application from one or more fluid-contacting surfaces of the sensor;

a signal receiver configured to receive complex admittance data from a plurality of fluid-contacting surfaces of the sensor;

a controller configured to coordinate the application of signals from the signal generator and the acquisition of complex admittance data from the sensor to create an admittance spectrographic fingerprint of the intravenous drug solution, wherein the controller is configured to apply electrical excitation to each pair of electrodes that results in a voltage that is below 500 mV and below the threshold level for electrochemical reactions, further wherein the admittance spectrographic fingerprint comprises complex admittance information indicative of surface interactions between the intravenous drug solution and the fluid-contacting surfaces of the sensor; and

a processor configured to receive the admittance spectrographic fingerprint and to determine the identity, concentration or identity and concentration of the intravenous drug solution by comparing the admittance spectrographic fingerprint to a library of admittance spectrographic data comprising complex admittance data measured from a plurality of known compounds and mixtures of compounds in a carrier solution at a plurality of frequencies and known concentrations.

2. The system of claim 1, wherein the fluid-contacting surfaces of each pair of electrodes in the plurality of electrodes of the sensor are formed of different materials.

3. The system of claim 1, wherein the fluid-contacting surfaces of each pair of electrodes in the plurality of electrodes of the sensor are formed of different geometries.

4. The system of claim 1, wherein the sensor comprises at least three different fluid-contacting surfaces formed of different materials, different geometries or different materials and geometries.

5. The systems of claim 1, wherein the sensor is configured to be single-use.

6. The system of claim 1, wherein the fluid-contacting surfaces of the sensor are calibrated to a predetermined standard that matches complex admittance data of the library of admittance spectrographic data.

7. The system of claim 1, further comprising a measurement cell configured to receive the intravenous drug solution so that the fluid-contacting surfaces of the sensor contact the intravenous drug solution.

8. The system of claim 1, wherein the signal generator is configured to apply an electrical excitation frequency from about 1 Hz to about 1 MHz.

9. The system of claim 1, further comprising a display configured to display the identity and concentration of the one or more compounds within the intravenous solution.

10. The system of claim 1, wherein the processor is further configured to determine the identity of the carrier solution of the intravenous drug solution.

11. The system of claim 1, wherein the library of predetermined complex admittance data comprises complex admittance data measured for a plurality of individual compounds and mixtures of compounds in a carrier solution at a plurality of frequencies.

12. The system of claim 1, wherein the processor comprises recognition logic configured to determine the likeliest match between the admittance spectrographic fingerprint and the library of admittance spectrographic data.

13. The system of claim 12, wherein the recognition logic comprises an adaptive neural network trained on the library of admittance spectrographic data.

14. The system of claim 1, wherein the sensor further comprises a second sensor element, and further wherein the processor is configured to use data from the second sensor element in addition to the complex admittance data to determine both the identity and the concentration one or more compounds in the intravenous drug solution.

15. The system of claim 14, wherein the second sensor element comprises an optical sensor.

16. A benchtop drug solution analyzer for determining the identity, concentration or identity and concentration of a drug solution by admittance spectroscopy to determine surface interactions of the drug solution on fluid-contacting surfaces of a plurality of electrodes, the analyzer comprising:

a measurement cell comprising a plurality of electrodes having fluid-contacting surfaces, the measurement cell configured to receive a sample of the drug solution so that the drug solution is contacted by the plurality of electrodes;

a signal generator configured to provide electrical excitation at a plurality of frequencies for application from a plurality of pairs of electrodes of the measurement cell, wherein each pair of electrodes is configured to have different surface interactions with the solution at different frequencies than the other pairs of electrodes;

a signal receiver configured to receive complex admittance data from the plurality of pairs of electrodes of the measurement cell;

a controller configured to coordinate the application of signals from the signal generator, and the acquisition of complex admittance data from the signal receiver, to create an admittance spectrographic fingerprint of the drug solution, wherein the controller is configured to apply electrical excitation to each pair of electrodes that results in a voltage that is below 500 mV and below the threshold level for electrochemical reactions, further wherein the admittance spectrographic fingerprint comprises complex admittance information indicative of surface interactions between the drug solution and the fluid-contacting surfaces; and

a processor configured to receive the admittance spectrographic fingerprint and to determine the identity, concentration or identity and concentration of one or more compounds in the drug solution by comparing the admittance spectrographic fingerprint to a library of admittance spectrographic data comprising complex admittance data measured from a plurality of known compounds and mixtures of compounds in a carrier solution at a plurality of frequencies and known concentrations.

17. The analyzer of claim 16, further comprising a housing at least partially enclosing the signal generator, single receiver and controller.

18. The analyzer of claim 16, further comprising a plurality of single-use measurement cells.

19. The analyzer of claim 16, wherein the measurement cell comprises at least three different fluid-contacting surfaces formed of different materials, different geometries or different materials and geometries.

20. The analyzer of claim 16, wherein the fluid-contacting surfaces of the measurement cell are calibrated to a predetermined standard that matches complex admittance data of the library of admittance spectrographic data.

21. The analyzer of claim 16, wherein the signal generator is configured to apply a current frequency from about 1 Hz to about 1 MHz.

22. The analyzer of claim 16, further comprising a display configured to display the identity and concentration of the one or more compounds within the drug solution.

23. The analyzer of claim 16, wherein the processor is further configured to determine the identity of the carrier solution of the drug solution.

24. The analyzer of claim 16, wherein the library of predetermined complex admittance data comprises complex admittance data measured for a plurality of individual compounds and mixtures of compounds in a carrier solution at a plurality of frequencies.

25. The system of claim 16, wherein the processor is configured to receive the admittance spectrographic fingerprint and to simultaneously determine identity and concentration of one or more compounds in the drug solution.

26. The analyzer of claim 16, wherein the processor comprises recognition logic configured to determine the likeliest match between the admittance spectrographic fingerprint and the library of admittance spectrographic data.

27. The analyzer of claim 26, wherein the recognition logic comprises an adaptive neural network trained on the library of admittance spectrographic data.

28. The analyzer of claim 16, wherein the measurement cell further comprises a second sensor element, and further wherein the processor is configured to use data from the second sensor element in addition to the admittance spectrographic fingerprint to determine both the identity and the concentration of one or more compounds in the drug solution.

29. The system of claim 28, wherein the second sensor element comprises an optical sensor.