Measurement device, measurement method, measurement result processing device, measurement system, measurement result processing method, control program, and recording medium

• US 9,173,604 B2
• Filed: 11/17/2010
• Issued: 11/03/2015
• Est. Priority Date: 03/19/2010
• Status: Active Grant

• Current Assignee: Sharp Life Science Corporation
• Original Assignee: Sharp Kabushiki Kaisha (Hon Hai Precision Industry Co., Ltd.)
• Inventors: Yamanaka, Mikihiro, Hijikuro, Megumi, Hara, Keita
• Primary Examiner(s): Le, Long V
• Assistant Examiner(s): Negarestan, Farshad
• Application Number:
  US13/635,629
• Publication Number:
  US 20130030306A1
• Time in Patent Office: 1,812 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/185 Optical shielding, e.g. baffles
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/489 Blood vessels
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/6835 Supports or holders, e.g., articulated arms
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots

Abstract

A measurement device (1) includes a probe (7) which irradiates a specific part or a specific location of a living body with excitation light and which receives fluorescence generated by irradiating the specific part or the specific location with excitation light.

Claims

1. A measurement system, comprising:

a measurement device for acquiring measurement data of fluorescence generated by irradiating a target measurement part of a living body with excitation light; and

a measurement result processing device which processes the measurement data acquired by the measurement device,

said measurement device including;

a light-shielding section for shielding environment light which is directed toward the target measurement part of the living body;

an excitation light source for irradiating the target measurement part of the living body with excitation light; and

a detector for generating the measurement data by analyzing the fluorescence generated by irradiating the target measurement part with the excitation light, said measurement result processing device including;

a feature extraction section configured to extract a fluorescence characteristic of fluorescence emitted from the target measurement part, which fluorescence is obtained by irradiating, with excitation light, the target measurement part of a living body;

a substance amount specifying section configured to specify an amount of fluorescent substances contained in the target measurement part on the basis of the fluorescence characteristic extracted by the feature extraction section;

a damage degree determination section configured to determine a damage degree indicative of a degree of damage received by the target measurement part or a part of the target measurement part on the basis of the amount of fluorescent substances specified by the substance amount specifying section;

an age calculation section for calculating measurement part age indicative of how aging of the target measurement part progresses on the basis of actual age of the living body and the damage degree of the target measurement part, the actual age being entered to the measurement result processing device, the damage degree being determined by the damage degree determination section; and

a correlation information storage section configured to store first correlation information indicative of a correlation between (I) the actual age of the living body, the average life expectancy, and the damage degree, and (II) the measurement part age,

the age calculation section calculating the measurement part age by use of formula as the first correlation information;

Measurement part age=Average life expectancy−

(Average life expectancy/Damage degree)+(Actual age-10).

2. The measurement system as set forth in claim 1, wherein:

the correlation information storage section further stores second correlation information indicative of a correlation between the amount of fluorescent substances and the damage degree of the target measurement part; and

the damage degree determination section determines the damage degree on the basis of the amount of fluorescent substances by use of the second correlation information.

3. The measurement system as set forth in claim 1,

wherein the age calculation section specifies the average life expectancy on the basis of gender and the actual age of the living body, the gender and the actual age being entered to the measurement result processing device.

4. The measurement system as set forth in claim 1,

wherein the feature extraction section is configured to extract, as the fluorescence characteristic, a peak fluorescent intensity in a predetermined range of wavelength from a spectrum of fluorescence of the target measurement part obtained by irradiating, with excitation light, the target measurement part.

5. The measurement system as set forth in claim 1,

wherein the substance amount specifying section is configured to specify an amount of advanced glycation end products contained in the target measurement part.

6. The measurement system as set forth in claim 1, further comprising

a display control unit for controlling a display section to display a result of processing carried out by the measurement result processing device.

7. The measurement system as set forth in claim 1, wherein the target measurement part includes a blood vessel and wherein:

the feature extraction section configured to extract the fluorescence characteristic of the fluorescence emitted from the blood vessel, which fluorescence is obtained by irradiating, with excitation light, the blood vessel of the target measurement part;

the substance amount specifying section configured to specify the amount of fluorescent substances contained in the blood vessel;

the damage degree determination section configured to determine the blood vessel wall damage degree indicative of a degree of damage of a blood vessel wall on the basis of the amount of fluorescent substances in the blood vessel;

the age calculation section configured to calculate a blood vessel age on the basis of the actual age of the living body, the average life expectancy, and the blood vessel wall damage degree; and

the measurement device, further includes;

a blood vessel visualizing light source for visualizing the blood vessel of the target measurement part by irradiating the target measurement part; and

a camera section for capturing the target measurement part irradiated with light of the blood vessel visualizing light source.

8. A measurement result processing method executed by a processor based on measurement data of fluorescence generated by irradiating a target measurement part of a living body with a measurement device, said measurement device including:

a light-shielding section for shielding environment light which is directed toward the target measurement part of the living body;

an excitation light source for irradiating the target measurement part of the living body with excitation light; and

a detector for generating the measurement data by analyzing the fluorescence generated by irradiating the target measurement part with the excitation light, the method comprising;

(I) extracting a fluorescence characteristic in fluorescence from the measurement data;

(II) specifying an amount of fluorescent substances contained in the target measurement part on the basis of the fluorescence characteristic extracted in the step (I);

(III) determining a damage degree indicative of a degree of damage received by the target measurement part or a part of the target measurement part on the basis of the amount of fluorescent substances specified in the step (II);

(IV) calculating measurement part age indicative of how aging of the target measurement part progresses on the basis of actual age of the living body, an average life expectancy specified based on the actual age, and the damage degree of the target measurement part, the actual age being entered to the processor, the damage degree being determined in the step (III); and

storing first correlation information indicative of a correlation between (I) the actual age of the living body, the average life expectancy, and the damage degree, and (II) the measurement part age,

the measurement part age calculation step calculating the measurement part age by use of formula as the first correlation information;

Measurement part age=Average life expectancy−

(Average life expectancy/Damage degree)+(Actual age-10).