Device and method for the ablation of fibrin sheath formation on a venous catheter

• US 9,173,704 B2
• Filed: 06/19/2009
• Issued: 11/03/2015
• Est. Priority Date: 06/20/2008
• Status: Active Grant

• Current Assignee: AngioDynamics, Inc.
• Original Assignee: AngioDynamics, Inc.
• Inventors: Hobbs, Eamonn P., Hamilton, William C. Jr.
• Primary Examiner(s): DELLA, JAYMI E
• Application Number:
  US12/488,070
• Publication Number:
  US 20090318849A1
• Time in Patent Office: 2,328 Days
• Field of Search: 604/20, 604/22, 606/48, 606/50, 606 27- 31, 607101-102, 607/116
• US Class Current: 1/1
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00357 Endocardium
• CPC Class Codes: A61B 2018/00386 Coronary vessels
• CPC Class Codes: A61B 2018/00613 Irreversible electroporation reversible electroporation A61N1/327
• CPC Class Codes: A61B 2018/00839 Bioelectrical parameters, e.g. ECG, EEG
• CPC Class Codes: A61B 2018/0097 Cleaning probe surfaces
• CPC Class Codes: A61M 2025/0019 Cleaning catheters or the like, e.g. for reuse of the device, for avoiding replacement
• CPC Class Codes: A61M 2205/054 with electrotherapy
• CPC Class Codes: A61M 25/0043 characterised by structural features
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

An indwelling venous catheter and method capable of destroying undesirable cellular growth is provided. The catheter includes a shaft having at least one lumen and adapted to be placed inside a vein for long term use. A plurality of electrodes are positioned near a distal section of the shaft and are adapted to receive from a voltage generator a plurality of electrical pulses in an amount sufficient to cause destruction of cells in the undesirable cellular growth that have grown around the shaft. In one aspect of the invention, a probe is configured to be removably insertable into the at least one lumen and the electrodes are positioned near the distal section of the probe.

Claims

1. A method of treating undesirable cellular growth on an indwelling venous catheter comprising:

connecting a voltage generator to a plurality of electrodes that are positioned on a shaft of the indwelling venous catheter;

applying a predetermined schedule of electrical pulses generated by the voltage generator between the plurality of connected electrodes while the shaft of the indwelling venous catheter is positioned inside a vessel the predetermined schedule of electrical pulses being of an amount sufficient to prevent the undesirable cellular growth around the shaft of the indwelling venous catheter and to electroporate cells of the undesirable cellular growth that may have formed around the shaft of the indwelling venous catheter; and

introducing a therapeutic agent into the electroporated cells of the undesirable cellular growth;

wherein the therapeutic. agent is formulated to cause cell death in the electroporated cells.

2. The method of claim 1, further comprising:

receiving electrocardiogram (ECG) signals from a synchronization device, wherein generation of the electrical pulses by the voltage generator is based on the received ECG signals.

3. The method of claim 1, wherein the therapeutic drug is a cytotoxic agent.

4. The method of claim 1, wherein the plurality of electrodes are ring shaped and located near a distal end of the indwelling venous catheter.

5. The method of claim 1, wherein the plurality of electrodes arc spiral shaped and located as segmented portions along a distal end of the indwelling venous catheter.

6. The method of claim 1, wherein the predetermined schedule of electrical pulses is sufficient to cause permanent pore formation in the cellular membrane of the undesirable cellular growth around the shaft of the indwelling venous catheter.

7. The method of claim 1, wherein the indwelling venous catheter further comprises an electrical concluding element and a surface of the indwelling venous catheter has skives or pockets filled with electrically conductive material.

8. The method of claim 1, wherein the predetermined schedule of electrical pulses are simultaneously applied to all of the plurality of connected electrodes with alternating polarity.

9. The method of claim 1, wherein the predetermined schedule of electrical pulses creates permanent openings in the undesirable cellular growth without creating a significant thermal effect to the undesirable cellular growth.

10. The method of claim 9, wherein the undesirable cellular growth contains at least smooth muscle cells that will remain after the predetermined schedule of electrical pulses and will be removed by natural body processes.