Pharmaceutical preparations for treatments of diseases and disorders of the breast
First Claim
1. A method for treating a benign disease or disorder of the breast, chest or underlying musculature comprisingtopically administering to the breast of a patient in need thereof a drug formulation comprisinga drug selected from the group consisting of an luteinizing hormone-releasing hormone (LHRH), danazol, and bromocriptine in an amount effective to provide regional, not systemic, relief from benign diseases or disorders of the breast, the drug dissolved or suspended in a hydroalcoholic pharmaceutical carrier comprising a N-methyl-2-pyrrolidone or 2-pyrrolidone, transdermal penetration enhancer to promote delivery of the drug across the stratum corneum.
2 Assignments
0 Petitions
Accused Products
Abstract
Formulations for topical or local administration of drugs directly to the breast or chest to produce a regional or local effect with lower systemic drug levels than when an effective amount is administered systemically are disclosed herein. In a preferred embodiment, the drug is administered to the surface of the breast, areola, or directly to the nipple. The formulations provide increased patient comfort, increased bioavailability and relatively high blood levels in the region to be treated with a reduction of side effects compared to those administered systemically. The preferred formulations contain drugs in the form of micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or carrier. The excipient or carrier may modify the release rates or enhance absorption into the affected area. The drug formulation may be in the form of a cream, lotion or foam.
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Citations
13 Claims
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1. A method for treating a benign disease or disorder of the breast, chest or underlying musculature comprising
topically administering to the breast of a patient in need thereof a drug formulation comprising a drug selected from the group consisting of an luteinizing hormone-releasing hormone (LHRH), danazol, and bromocriptine in an amount effective to provide regional, not systemic, relief from benign diseases or disorders of the breast, the drug dissolved or suspended in a hydroalcoholic pharmaceutical carrier comprising a N-methyl-2-pyrrolidone or 2-pyrrolidone, transdermal penetration enhancer to promote delivery of the drug across the stratum corneum.
Specification