Compositions comprising elemental metals

• US 9,173,900 B2
• Filed: 06/05/2006
• Issued: 11/03/2015
• Est. Priority Date: 06/03/2005
• Status: Expired due to Fees

• Current Assignee: Ben Franklin Technology Partners Of Southeastern Pennsylvania
• Original Assignee: Prezacor, Inc
• Inventors: Karpf, Gary
• Primary Examiner(s): Richter, Johann R
• Assistant Examiner(s): SULLIVAN, DANIELLE D
• Application Number:
  US11/921,477
• Publication Number:
  US 20110117179A1
• Time in Patent Office: 3,438 Days
• Field of Search: 424/420, 424/421, 424/485, 424/502
• US Class Current: 1/1
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/26 in coated particulate form
• CPC Class Codes: A01N 59/06 Aluminium; Calcium; Magnesium; Compounds thereof
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A01N 59/20 Copper
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/241 Lead; Compounds thereof
• CPC Class Codes: A61K 33/242 Gold; Compounds thereof
• CPC Class Codes: A61K 33/243 Platinum; Compounds thereof
• CPC Class Codes: A61K 33/244 Lanthanides; Compounds thereof medicinal preparations containing radioactive lanthanides for use in therapy or testing in vivo A61K51/00
• CPC Class Codes: A61K 33/26 Iron; Compounds thereof
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/146 with organic macromolecular compounds
• CPC Class Codes: A61K 9/148 with compounds of unknown constitution, e.g. material from plants or animals with oils, fats, waxes, shellac A61K9/145
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/5123 Organic compounds, e.g. fats, sugars
• CPC Class Codes: A61K 9/7023 : Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61L 15/18 : containing inorganic materials
• CPC Class Codes: A61L 15/44 : Medicaments
• CPC Class Codes: A61L 2300/102 : Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/41 : Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/624 : Nanocapsules
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 : Antipsoriatics
• CPC Class Codes: A61P 19/00 : Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 : for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 : Antineoplastic agents

Abstract

The invention provides compositions and devices for altering biological field effects and methods for their use in therapeutic and agricultural applications. In particular, the invention provides compositions including one or more elemental metals coated with one or more non-conducting or semi-conducting materials and methods for their application to animals (including humans) and/or plants.

Claims

1. A non-conducting composition for relieving pain, comprising substantially water-free particles of elemental iron, zinc, copper, and aluminum having an average diameter of less than about 100 microns, distributed within and separated by an insulating matrix substantially free of air pockets and comprising petroleum jelly, lanolin, silicone, wax, or combinations thereof, wherein the composition is non-conducting, wherein the distribution and separation of the particles within the matrix imparts capacitance into the composition, and wherein the capacitance of the composition alters an electrostatic field, an electromagnetic field, or both an electrostatic and an electromagnetic field of the human body or the body of a non-human mammal when the composition is brought into close proximity of or into contact with the human body or the body of a non-human mammal, thereby relieving pain in the human body or the body of the non-human mammal.

2. The non-conducting composition of claim 1, wherein the particles have an average diameter of less than about 40 microns.

3. The non-conducting composition of claim 1, wherein the ratio of elemental iron to elemental zinc is between 1000:

1 and 1;

1000.

4. The non-conducting composition of claim 1, wherein the ratio of elemental iron to elemental aluminum is between 1000:

1 and 1;

1000.

5. The non-conducting composition of claim 1, wherein the ratio of elemental iron to elemental copper is between 1000:

1 and 1;

1000.

6. A method of reducing pain in a human or non-human mammal in need thereof, comprising contacting a body surface of the human or non-human mammal near a region having pain with the non-conducting composition of claim 1.

7. The non-conducting composition of claim 1, wherein the composition is flexible, malleable, or rigid.

8. The non-conducting composition of claim 1, wherein the matrix protects the elemental iron, zinc, copper, and aluminum from oxidation.

9. The non-conducting composition of claim 1, wherein the composition is sticky.

10. The non-conducting composition of claim 1, wherein the composition comprises 29.6% by weight of iron, 25.6% by weight of zinc, and up to 10% by weight of aluminum and copper.

11. The non-conducting composition of claim 1, wherein the ratio of total metal particles to the matrix is between 1:

100 and 100;

1.

12. The non-conducting composition of claim 1, wherein the ratio of total metal particles to the matrix is between 1:

10 and 10;

1.

13. The non-conducting composition of claim 1, wherein the composition includes not more than 0.01% by weight of oxidized or reduced forms of the elemental iron, zinc, copper, and aluminum.

14. The non-conducting composition of claim 1, wherein the particles are capable of being sieved though a 200 mesh sieve.

15. The non-conducting composition of claim 1, wherein the particles are capable of being sieved though a 325 mesh sieve.

16. The non-conducting composition of claim 1, wherein the matrix comprises wax, and the wax comprises bees wax.

17. The non-conducting composition of claim 1, wherein the matrix comprises silicone.

18. The non-conducting composition of claim 1, wherein a fraction of the particles are separated by the matrix.

19. A non-conducting composition for relieving pain, comprising substantially water-free particles of elemental iron, zinc, copper, and aluminum having an average diameter of less than about 100 microns, distributed within and separated by an insulating matrix substantially free of air pockets and comprising petroleum jelly, lanolin, silicone, wax, or combinations thereof, wherein the composition is non-conducting, wherein the distribution and separation of the particles within the matrix imparts capacitance into the composition, and wherein the capacitance of the composition alters an electrostatic field, an electromagnetic field, or both an electrostatic and an electromagnetic field of the human body when the composition is brought into close proximity of or into contact with the human body, thereby relieving pain in the human body.

20. The non-conducting composition of claim 19, wherein the particles have an average diameter of less than about 40 microns.

21. The non-conducting composition of claim 19, wherein the ratio of elemental iron to elemental zinc is between 1000:

1 and 1;

1000.

22. The non-conducting composition of claim 19, wherein the ratio of elemental iron to elemental aluminum is between 1000:

1 and 1;

1000.

23. The non-conducting composition of claim 19, wherein the ratio of elemental iron to elemental copper is between 1000:

1 and 1;

1000.

24. The non-conducting composition of claim 19, wherein the matrix comprises silicone.

25. The non-conducting composition of claim 19, wherein a fraction of the particles are separated by the matrix.

31. A method of reducing pain in a human in need thereof, comprising bringing the composition of claim 19 into proximity with a surface of the human body near a painful region of the body, thereby reducing pain in the painful region.

32. A method of reducing pain in a human in need thereof, comprising contacting the composition of claim 19 with a surface of the human body near a painful region of the body, thereby reducing pain in the painful region.

26. A device for relieving pain in a subject, the device comprising a support, and a non-conducting composition affixed to the support, the non-conducting composition comprising substantially water-free particles of elemental iron, zinc, copper, and aluminum having an average diameter of less than about 100 microns, distributed within and separated by an insulating matrix substantially free of air pockets and comprising petroleum jelly, lanolin, silicone, wax, or combinations thereof, wherein the distribution and separation of the particles within the matrix imparts capacitance into the composition, and wherein the capacitance of the composition alters an electrostatic field, an electromagnetic field, or both an electrostatic and an electromagnetic field of the body of the subject when the composition is brought into close proximity of or into contact with the body, thereby relieving pain in the subject.

27. The device of claim 26, wherein the matrix comprises silicone.

28. The device of claim 26, wherein a fraction of the particles are separated by the matrix.

29. The device of claim 26, wherein the device is a patch.

30. The device of claim 26, wherein the device is shaped to conform and adhere to the surface of a desired body part.

33. A method of reducing pain in a human in need thereof, comprising contacting the device of claim 26 with a surface of the human body near a painful region of the body, thereby reducing pain in the painful region.

34. The method of claim 33, wherein the device is a patch.