Methods and compositions for tissue regeneration
First Claim
1. A composition comprising mitotically inactive autologous or allogeneic cells that are capable of secreting one or more biologically active molecules selected from GM-CSF, VEGF, KGF, aFGF, bFGF, TGFβ
- , angiopoietin, EGF, IL-1β
, IL-6, IL-8, PDGF, HGF/SF, IGF-1, CSF-1, TGFα
, and TNFα
, wherein the composition is comprised in a buffered solution, a wound dressing, or an extracellular matrix or matrix material.
6 Assignments
0 Petitions
Accused Products
Abstract
A kit is disclosed that includes a first component comprising alginate, wherein the first component is comprised in a first sterile vile, and a second component comprising cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting of GM-CSF, VEGF, KGF, bFGF, TGFβ, angiopoietin, EGF, IL-Iβ, TGFα, and TNFα, wherein the cells are allogeneic and mitotically inactive, a buffered solution, and human serum albumin or a cryoprotectant, wherein the second component is comprised in a second vial.
31 Citations
20 Claims
-
1. A composition comprising mitotically inactive autologous or allogeneic cells that are capable of secreting one or more biologically active molecules selected from GM-CSF, VEGF, KGF, aFGF, bFGF, TGFβ
- , angiopoietin, EGF, IL-1β
, IL-6, IL-8, PDGF, HGF/SF, IGF-1, CSF-1, TGFα
, and TNFα
, wherein the composition is comprised in a buffered solution, a wound dressing, or an extracellular matrix or matrix material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- , angiopoietin, EGF, IL-1β
Specification