Coatings for drug delivery devices

• US 9,173,982 B2
• Filed: 01/04/2013
• Issued: 11/03/2015
• Est. Priority Date: 11/12/2001
• Status: Active Grant

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Pacetti, Stephen Dirk
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): YOUNG, MICAH PAUL
• Application Number:
  US13/734,860
• Publication Number:
  US 20130150459A1
• Time in Patent Office: 1,033 Days
• Field of Search: 424489-495, 424422-426
• US Class Current: 1/1
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/30 Inorganic materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: C08L 29/02 Homopolymers or copolymers of unsaturated alcohols C08L29/14 takes precedence
• CPC Class Codes: C09D 129/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C09D 129/06 Copolymers of allyl alcohol

Abstract

A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.

Claims

1. A coating for a medical device, the coating comprising a polymer having at least one unit (I):

—

[CH₂—

CHR¹]—

 

 

(I)

and at least one unit (II);

—

[CH₂—

CR²(CH₂OH)]—

 

 

(II)

wherein the coating is capable of containing a drug, and

wherein R¹ is selected from a group consisting of hydrogen and an alkyl group; and

R² is an alkyl group.

2. The coating of claim 1, wherein the alkyl group is methyl.

3. The coating of claim 1, wherein the polymer absorbs not more than 5% of water by mass.

4. The coating of claim 1, wherein the polymer is soluble in an organic solvent.

5. The coating of claim 1, wherein the polymer has a tensile strength of not less than about 24 MPa (3,500 pounds per square inch).

6. The coating of claim 1, wherein the polymer has an ultimate elongation exceeding 30%.

7. A coating for a stent, the coating comprising a polymer having at least one unit (I):

—

[CH₂—

CHR¹]—

 

 

(I)

and at least one unit (II);

—

[CH₂—

CR²(CH₂OH)]—

 

 

(II)

wherein R¹ is selected from a group consisting of a hydrogen atom and an alkyl group; and

R² is an alkyl group, wherein the coating contains a drug.

8. The coating of claim 7, wherein each of R¹ and R² is independently an alkyl group.

9. The coating of claim 8, wherein the alkyl group is methyl.

10. The coating of claim 7, wherein the polymer absorbs not more than 5% of water by mass.

11. The coating of claim 7, wherein the polymer is soluble in an organic solvent.

12. The coating of claim 7, wherein the polymer has a tensile strength of not less than about 24 MPa (3,500 pounds per square inch).

13. The coating of claim 7, wherein the polymer has an ultimate elongation exceeding 30%.

14. The coating of claim 7, wherein the coating is a primer layer.

15. The coating of claim 7, wherein the coating is a rate release limiting membrane.