Apparatus and methods for conducting assays and high throughput screening
First Claim
1. A method of conducting cellular analysis, comprising(a) providing a suspension of cells,(b) labeling at least a portion of the cells with a labeled ligand,(c) introducing the cells into a channel configured and arranged to deliver a plurality of individual cells from the suspension into a mass spectrometer,(d) measuring the label from the plurality of individual cells by mass spectrometry to determine a property of the individual cells.
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Accused Products
Abstract
The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.
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Citations
17 Claims
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1. A method of conducting cellular analysis, comprising
(a) providing a suspension of cells, (b) labeling at least a portion of the cells with a labeled ligand, (c) introducing the cells into a channel configured and arranged to deliver a plurality of individual cells from the suspension into a mass spectrometer, (d) measuring the label from the plurality of individual cells by mass spectrometry to determine a property of the individual cells.
Specification