Effective-inductance-change based magnetic particle sensing
First Claim
1. An integrated measurement system to detect a quantity of magnetic particles in a sample, the system comprising:
- a substrate having a surface;
first and second sample delivery structures;
a first electromagnetic (EM) structure disposed on said surface of said substrate and configured to receive, via said first sample delivery structure, a sample comprising said magnetic particles in proximity thereof;
an electrical current generator disposed on said surface of said substrate and electromagnetically coupled to said first EM structure, said electrical current generator configured to cause an electrical current to flow in said first EM structure;
a sensing oscillator electrically coupled to said first EM structure, said sensing oscillator comprising a selected one of a self inductance sensor and a mutual inductance sensor, said sensing oscillator disposed on said surface of said substrate and configured to measure a selected one of an effective inductance and a change in effective inductance; and
a second EM structure disposed on said surface of said substrate, wherein said second EM structure is configured to receive a control solution via said second sample delivery structure;
said integrated measurement system being configured to detect said quantity of said magnetic particles based on a differential sensing measurement that is based on a first signal associated with said first EM structure and a second signal associated with said second EM structure.
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Accused Products
Abstract
The invention relates to an integrated measurement system to detect a quantity of magnetic particles in a sample. The measurement system includes a substrate. An electromagnetic (EM) structure disposed on the surface of the substrate is configured to receive a sample including the magnetic particles in proximity thereof. The integrated measurement system also includes an electrical current generator disposed on the surface of the substrate which is electro-magnetically coupled to the EM structure. The electrical current generator is configured to cause an electrical current to flow in the EM structure. The integrated measurement system also includes an effective inductance sensor disposed on the surface of the substrate which is configured to measure a selected one of an effective inductance and a change in effective inductance. The invention also relates to a method to determine the number of and/or the locations of the magnetic particles in a sample.
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Citations
20 Claims
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1. An integrated measurement system to detect a quantity of magnetic particles in a sample, the system comprising:
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a substrate having a surface; first and second sample delivery structures; a first electromagnetic (EM) structure disposed on said surface of said substrate and configured to receive, via said first sample delivery structure, a sample comprising said magnetic particles in proximity thereof; an electrical current generator disposed on said surface of said substrate and electromagnetically coupled to said first EM structure, said electrical current generator configured to cause an electrical current to flow in said first EM structure; a sensing oscillator electrically coupled to said first EM structure, said sensing oscillator comprising a selected one of a self inductance sensor and a mutual inductance sensor, said sensing oscillator disposed on said surface of said substrate and configured to measure a selected one of an effective inductance and a change in effective inductance; and a second EM structure disposed on said surface of said substrate, wherein said second EM structure is configured to receive a control solution via said second sample delivery structure; said integrated measurement system being configured to detect said quantity of said magnetic particles based on a differential sensing measurement that is based on a first signal associated with said first EM structure and a second signal associated with said second EM structure. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An integrated measurement system configured to detect a quantity of magnetic particles in a first sample, the system comprising:
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a substrate having a surface; a first electromagnetic (EM) structure disposed on said surface of said substrate and configured to receive a first sample comprising said magnetic particles in proximity thereof; an electrical current generator disposed on said surface of said substrate and electromagnetically coupled to said first EM structure, said electrical current generator configured to cause an electrical current to flow in said first EM structure; a sensing oscillator disposed on said surface of said substrate and configured to provide an indication of a selected one of an effective inductance and a change in effective inductance associated with said first EM structure; a second EM structure disposed on said surface of said substrate and configured to receive a second sample in proximity thereof; a reference oscillator disposed on said surface of said substrate and configured to provide an indication of a selected one of an effective inductance and a change in effective inductance associated with said second EM structure; wherein said integrated measurement system is configured to make a differential sensing measurement to detect said quantity of said magnetic particles based on a difference between a first signal associated with said sensing oscillator and a second signal associated with said reference oscillator. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 19)
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17. The measurement system of 7, wherein said integrated measurement system comprises a CMOS structure.
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18. The measurement system of 7, wherein said electrical current generator comprises a quasi-static electrical current generator.
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20. The measurement system of 7, wherein said sensing oscillator comprises a low noise oscillator.
Specification