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Techniques, systems and machine readable programs for magnetic resonance

  • US 9,176,208 B2
  • Filed: 10/21/2014
  • Issued: 11/03/2015
  • Est. Priority Date: 03/23/2011
  • Status: Active Grant
First Claim
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1. A method for performing magnetic resonance spectroscopic imaging comprising:

  • a) providing a magnetic resonance device including (i) a main magnet for providing a background magnetic field along a first direction, (ii) at least one radio-frequency coil configured to resonate with the Larmor frequency of 19F, and (iii) at least one gradient coil configured to be controlled to define a region of interest;

    b) positioning a supplemental spin reservoir within a field of view of the at least one resonant coil, the supplemental spin reservoir (SSR) including a plurality of molecules, at least some of the molecules including 19F;

    c) administering a composition including at least one biomarker or precursor of a biomarker molecule including 19F to a sample or a subject to be imaged;

    d) introducing the sample or the subject to be studied into the field of view;

    e) introducing RF pulses into the sample or subject;

    f) collecting three dimensional spatial data for a set of nuclei of interest including 19F from at least one of the (i) sample or subject, and (ii) the SSR;

    g) after step (f), inducing feedback between the nuclear magnetization of the set of nuclei of interest and the at least one radio frequency coil to cause the vector direction of the nuclear magnetization of the set of nuclei of interest to rotate to a desired angle.

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