Sensing device for body tissue properties

• US 9,179,856 B2
• Filed: 04/17/2009
• Issued: 11/10/2015
• Est. Priority Date: 04/17/2009
• Status: Active Grant

• Current Assignee: Biosigns Pte Limited
• Original Assignee: Biovotion AG (Biofourmis AG)
• Inventors: Caduff, Andreas, Talary, Mark Stuart, Krebs, Hans-Joachim, Megej, Alexander, Dewarrat, Francois
• Primary Examiner(s): D'Angelo, Michael
• Assistant Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US13/264,774
• Publication Number:
  US 20120095307A1
• Time in Patent Office: 2,398 Days
• Field of Search: 600/345, 600/347, 600/365
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/6828 Leg

Abstract

A device is described for measuring a parameter of living tissue, in particular a glucose level, which parameter affects a response of said tissue to an electric field. The device comprises a substrate (2), which carries a ground electrode (10) as well as a plurality of signal electrodes (12a, 12b, 13a-13c, 14). The gaps (15) between the ground electrode and the signal electrodes are filled with a solid filler material (16) in order to provide an even surface. Optical reflection detectors (23a, 23b, 23c) can also be located in these gaps in order to avoid field distortions and obtain a compact design. The backside of substrate (2) carries electronic high-frequency components for improving signal quality.

Claims

1. A device for measuring a parameter of living tissue, which parameter affects a response of said tissue to an electric field, said device comprising

a substrate (2),

an electrode arrangement (10, 12a, 12b, 13a-13c, 14) comprising at least a first and a second electrode and being mounted on a first side of said substrate (2), wherein said first and second electrodes are separated by a gap (15),

a control unit (30) adapted to determine the response of said tissue to the electric field generated by said electrodes,

wherein said gap (15) is filled at least partially with a solid (16), and

wherein said device further comprises at least one optical reflection sensor (23a-c), and wherein said at least one optical reflection sensor (23a-c) extends into said gap (15).

2. The device of claim 1, wherein said substrate (2) has a flat surface (17) on said first side and wherein said first and second electrodes are mounted on said flat surface (17).

3. The device of claim 1, wherein said optical reflection sensor (23a-c) extends into or through an opening (24) in said substrate (2), and wherein said opening (14) ends in said gap (15).

4. The device of claim 1, wherein said optical reflection sensor (23a-c) comprises at least one light source (27a, 27b, 27c) and at least one light detector (28a, 28b) covered by a transparent window (29), wherein said window (29) is located at least partially in said gap (15).

5. The device of claim 4, wherein said optical reflection sensor (23a-c) comprises two light detectors (28a, 28b), and wherein said at least one light source (27a, 27b, 27c) is located between said two light detectors.

6. The device of claim 5, wherein said optical reflection detector comprises a first light source (27a) generating light at a wavelength below 600 nm, a second light source (27b) generating light at a wavelength above 700 nm, and a third light source (27c) generating light at a wavelength between 600 and 700 nm.

7. The device of claim 4, wherein said optical reflection detector comprises a first light source (27a) generating light at a wavelength below 600 nm and a second light source (27b) generating light at a wavelength above 700 nm.

8. The device of claim 1, wherein said electrode arrangement (10, 12a, 12b, 13a-5 13c, 14) comprises a ground electrode (10) and several signal electrodes (12a, 12b, 13a-13c, 14) on said first side of said substrate (2), wherein said signal electrodes (12a, 12b, 13a-13c, 14) are arranged in openings of said ground electrode (10), and wherein said gaps (15) are formed between inner edges of said openings and outer edges of said signal electrodes (12a, 12b, 13a-13c, 14).

9. The device of claim 1, wherein the parameter is a glucose level.

10. A device for measuring a parameter of living tissue, which parameter affects a response of said tissue to an electric field, said device comprising

a substrate (2),

an electrode arrangement (10, 12a, 12b, 13a-13c, 14) comprising at least a first and a second electrode and being mounted on a first side of said substrate (2), wherein said first and second electrodes are separated by a gap (15),

a control unit (30) adapted to determine the response of said tissue to the electric field generated by said electrodes,

wherein said gap (15) is filled at least partially with a solid (16),

wherein said electrode arrangement (10, 12a, 12b, 13a-5 13c, 14) comprises a ground electrode (10) and several signal electrodes (12a, 12b, 13a-13c, 14) on said first side of said substrate (2), wherein said signal electrodes (12a, 12b, 13a-13c, 14) are arranged in openings of said ground electrode (10), and wherein said gaps (15) are formed between inner edges of said openings and outer edges of said signal electrodes (12a, 12b, 13a-13c, 14),

said device further comprising

a first set (12a, 12b) of signal electrodes surrounded by gaps (15) of different widths,

a second set (13a-13c) of signal electrodes surrounded by gaps (15) of different widths,

a first signal generator (33) connected to said first set (12a, 12b) of signal electrodes and operating at a frequency of at least 1 GHz, and

a second signal generator (32) connected to said second set (13a-13c) of signal electrodes and operating at a frequency between 0.1 and 500 MHz.

11. The device of claim 10, wherein said first and second sets of signal electrodes are elongate strip electrodes, wherein the electrodes in each set extend parallel to each other and perpendicular to the electrodes of the other set,

and wherein said device comprises a band (4) for attaching said device on an arm or leg, wherein said band extends perpendicularly to an axis (3) of said device, wherein the signal electrodes of said first set (12a, 12b) extend perpendicularly to said axis (3) and/or the signal electrodes of said second set (13a-13c) extend parallel to said axis (3).

12. The device of claim 10, wherein said substrate (2) comprises a shield electrode (18a, 18b) embedded within said substrate (2), and wherein said shield electrode (18a, 18b) is electrically connected to said ground electrode.

13. The device of claim 10, wherein said shield electrode (18a, 18b) is at a first distance (D1) from said first set (12a, 12b) of signal electrodes and at a second distance (D2) from said second set (13a-13c) of signal electrodes, wherein said first distance (D1) is smaller than said second distance (D2), and wherein said first distance (D1) is smaller than 1 mm and said second distance (D2) is at least 1.5 mm.

14. The device of claim 10, wherein said interdigital electrodes (22) are arranged between said first and said second sets (12a, 12b;

13a-13c) of electrodes.

15. The device of claim 10, wherein the parameter is a glucose level.

16. A device for measuring a parameter of living tissue, which parameter affects a response of said tissue to an electric field, said device comprising

a substrate (2),

an electrode arrangement (10, 12a, 12b, 13a-13c, 14) comprising at least a first and a second electrode and being mounted on a first side of said substrate (2), wherein said first and second electrodes are separated by a gap (15), and

a control unit (30) adapted to determine the response of said tissue to the electric field generated by said electrodes,

wherein said gap (15) is filled at least partially with a solid (16),

wherein said electrode arrangement (10, 12a, 12b, 13a-5 13c, 14) comprises a ground electrode (10) and several signal electrodes (12a, 12b, 13a-13c, 14) on said first side of said substrate (2), wherein said signal electrodes (12a, 12b, 13a-13c, 14) are arranged in openings of said ground electrode (10), and wherein said gaps (15) are formed between inner edges of said openings and outer edges of said signal electrodes (12a, 12b, 13a-13c, 14),

said device further comprising at least one pair of electrodes designed as interdigital electrodes (22), and wherein said device further comprising a third signal generator (31) connected to said interdigital electrodes (22) and generating a signal at a frequency below 0.2 MHz.

17. The device of claim 16, further comprising a first signal generator (40) connected to at least one of said electrodes and generating a signal with a frequency of at least 1 GHz and a first signal detector (43) connected to at least one of said electrodes and detecting said signal of at least 1 GHz, wherein said first signal generator (40) and said first signal detector (43) are mounted to a second side of said substrate (2).

18. The device of claim 17, further comprising at least one printed circuit (7) in addition to said substrate (2), wherein said printed circuit (7) is electrically connected to said first signal detector (43) and said first signal generator (40).

19. The device of claim 18, wherein said electrodes comprise a copper layer and a gold layer, and wherein said gold layer forms a surface of said electrodes and is directly connected to said copper layer.

20. The device of claim 16, wherein the parameter is a glucose level.