Thermochromic polyvinyl alcohol based hydrogel artery
First Claim
1. A method of creating a thermochromic artificial blood vessel, the method comprising:
- physically cross-linking a polyvinyl alcohol solution at a temperature below 0°
C. in an arterial mold so as to form an artificial blood vessel, the polyvinyl alcohol solution including polyvinyl alcohol and water;
chemically cross-linking the physically cross-linked blood vessel with a chemical cross-linking solution, the chemical cross-linking solution including a chemical cross-linking reagent and water; and
applying a coagulation solution to the chemically cross-linked blood vessel to both inhibit the chemical cross-linking and promote physical cross-linking of the artificial blood vessel, thereby imparting to the artificial blood vessel the ability to change color and/or transparency at locations thereof where temperature increases, the coagulation solution including water, a base, and a cross-linking promoter.
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Accused Products
Abstract
A method of creating a thermochromic artificial blood vessel includes physically cross-linking a polyvinyl alcohol solution in a mold shaped to mimic a blood vessel to create an artificial blood vessel. The artificial tissue is then chemically cross-linked with a solution including a chemical cross-linking reagent. A coagulation solution is then applied to the artificial blood vessel to both inhibit the chemical cross-linking and promote physical cross-linking of the artificial blood vessel. The artificial blood vessel can be used to test an ablation catheter. The vessel, when heated by the ablation catheter, changes color and/or transparency at locations where the temperature of artificial blood vessel increases.
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Citations
16 Claims
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1. A method of creating a thermochromic artificial blood vessel, the method comprising:
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physically cross-linking a polyvinyl alcohol solution at a temperature below 0°
C. in an arterial mold so as to form an artificial blood vessel, the polyvinyl alcohol solution including polyvinyl alcohol and water;chemically cross-linking the physically cross-linked blood vessel with a chemical cross-linking solution, the chemical cross-linking solution including a chemical cross-linking reagent and water; and applying a coagulation solution to the chemically cross-linked blood vessel to both inhibit the chemical cross-linking and promote physical cross-linking of the artificial blood vessel, thereby imparting to the artificial blood vessel the ability to change color and/or transparency at locations thereof where temperature increases, the coagulation solution including water, a base, and a cross-linking promoter. - View Dependent Claims (2)
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3. A method of creating a thermochromic artificial tissue, the method comprising steps of:
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physically cross-linking a polyvinyl alcohol solution by freeze-thawing in a mold shaped to mimic an animal tissue so as to create the artificial tissue; chemically cross-linking the physically cross-linked tissue with a chemical cross-linking solution comprising a chemical cross-linking reagent; and applying a coagulation solution to the chemically cross-linked tissue to both inhibit the chemical cross-linking and promote physical cross-linking of the artificial tissue, thereby imparting to the artificial tissue the ability to change color and/or transparency at locations thereof where temperature increases. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification