Non-sedating antihistamine injection formulations and methods of use thereof

• US 9,180,090 B2
• Filed: 10/04/2012
• Issued: 11/10/2015
• Est. Priority Date: 07/03/2009
• Status: Active Grant

• Current Assignee: JDP Therapeutics, LLC
• Original Assignee: JDP Therapeutics, Inc.
• Inventors: Du, Jie
• Primary Examiner(s): Ricci, Craig
• Application Number:
  US13/644,290
• Publication Number:
  US 20130030010A1
• Time in Patent Office: 1,132 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/341 not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• CPC Class Codes: A61K 31/4164 1,3-Diazoles
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/4545 containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• CPC Class Codes: A61K 31/495 having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazinesA61K31/48 takes precedence ; with three nitrogen atoms A61K31/53
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14

Abstract

Disclosed are injectable formulations of cetirizine for treating acute allergic reactions and methods for treating acute allergic reactions. In particular, an intravenous injectable is disclosed as are methods of treating acute allergic reactions.

Claims

1. A method of treating a patient, comprising

administering to the patient an injectable formulation comprising 1 to 10 mg/mL of cetirizine or levocetirizine, or a pharmaceutically acceptable salt, or polymorph of the cetirizine or levocetirizine,

wherein the injectable formulation is free of hemolysis when contacted with a human blood sample, and

wherein the patient is in need of treatment for an acute allergic reaction.

2. The method of claim 1, wherein the acute allergic reaction is an allergic condition of the immediate type.

3. The method of claim 1, wherein the acute allergic reaction is anaphylaxis.

4. The method of claim 1, wherein the acute allergic reaction is a severe allergic reaction to blood or plasma, food, medication, or an allergy-inducing material.

5. The method of claim 1, wherein treating is in an emergency situation.