Compositions and devices incorporating water-insoluble therapeutic agents and methods of the use thereof
First Claim
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1. A medical device comprising:
- a base structure having a surface, anda coating on the surface comprising water-insoluble therapeutic agent solubilized within a matrix of tannic acid.
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Abstract
Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.
32 Citations
16 Claims
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1. A medical device comprising:
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a base structure having a surface, and a coating on the surface comprising water-insoluble therapeutic agent solubilized within a matrix of tannic acid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A medical device comprising:
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a base structure comprising and balloon or a stent, and a composition comprising tannic acid and a taxane agent, wherein the tannic acid and the taxane agent are present at a weight ratio of between 1 to 40 and 500 to 1 tannic acid to taxane agent. - View Dependent Claims (16)
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Specification