Portable hemodialysis machine and disposable cartridge

• US 9,180,237 B2
• Filed: 02/26/2015
• Issued: 11/10/2015
• Est. Priority Date: 02/27/2014
• Status: Active Grant

• Current Assignee: Diality, Inc.
• Original Assignee: Asit Engineering Corp.
• Inventors: Corder, Rodney, Giordano, Renato
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US14/632,421
• Publication Number:
  US 20150238678A1
• Time in Patent Office: 257 Days
• Field of Search: 604 401- 616
• US Class Current: 1/1
• CPC Class Codes: A61M 1/1524 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/156 Constructional details of the cassette, e.g. specific details on material or shape
• CPC Class Codes: A61M 1/15632 the filter being a dialyser
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1603 Regulation parameters
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1621 Constructional aspects thereof semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/1692 Detection of blood traces in dialysate
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/362227 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/36224 with sensing means or components thereof
• CPC Class Codes: A61M 1/36225 with blood pumping means or components thereof
• CPC Class Codes: A61M 1/36226 Constructional details of cassettes, e.g. specific details on material or shape
• CPC Class Codes: A61M 1/362264 the filter being a blood filter
• CPC Class Codes: A61M 1/3626 Gas bubble detectors
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/121 interface between cassette and base
• CPC Class Codes: A61M 2205/123 : with incorporated reservoirs
• CPC Class Codes: A61M 2205/125 : with incorporated filters
• CPC Class Codes: A61M 2205/15 : Detection of leaks
• CPC Class Codes: A61M 2205/3303 : Using a biosensor
• CPC Class Codes: A61M 2205/3331 : Pressure; Flow
• CPC Class Codes: A61M 2205/3334 : Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3368 : Temperature
• CPC Class Codes: A61M 2205/3379 : Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3653 : by Joule effect, i.e. electric resistance
• CPC Class Codes: A61M 2205/50 : with microprocessors or computers
• CPC Class Codes: A61M 60/113 : in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/279 : Peristaltic pumps, e.g. roller pumps
• CPC Class Codes: A61M 60/37 : Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/441 : generated by an electromotor
• CPC Class Codes: A61M 60/554 : of blood pressure
• CPC Class Codes: A61M 60/849 : Disposable parts
• CPC Class Codes: A61M 60/853 : the valve being formed by a flexible tube element which is clamped for restricting the flow

Abstract

A portable hemodialysis system is provided suitable for in home use. The hemodialysis system includes a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialyzer, and a dialysate flow path and a blood flow path which flow in opposing directions through the dialyzer. In addition, the disposable cartridge possesses pump actuators (but not pump motors) for pumping dialysate and blood through their respective flow paths. The pump actuators having non-deformable components including a housing having a central cavity forming an internal sidewall, a rotor eccentrically positioned within the cavity having radially aligned slots at the rotor'"'"'s periphery, and vanes slideably positioned in the slots to slide in and out of the slots so as to seal with the cavity'"'"'s internal sidewall creating vane chambers that pump blood or dialysate.

Claims

1. A hemodialysis system comprising:

an arterial blood line for connecting to a patient'"'"'s artery for collecting blood from a patient;

a venous blood line for connecting to a patient'"'"'s vein for returning blood to a patient;

a dialyzer;

a blood flow path connected to said arterial blood line and said venous blood line for transporting blood from a patient to said dialyzer and back to a patient;

a reservoir for storing a dialysate solution;

a dialysate flow path, isolated from the blood flow path, for transporting a dialysate from said reservoir to said dialyzer and back to said reservoir;

a filter connected to said dialysate flow path downflow from said dialyzer for removing uremic toxins from dialysate in said a dialysate flow path after said dialyzer and prior to returning said dialysate to said reservoir;

a first pump including a first pump motor and a first pump actuator connected to said dialysate flow path upflow from said dialyzer for pumping dialysate through said dialysate flow path to said dialyzer, said first pump actuator including a sliding vane construction having non-deformable components including a housing having a central cavity forming an internal sidewall, a rotor eccentrically positioned within said cavity and said rotor having a plurality of radially aligned slots at said rotor'"'"'s periphery, vanes slideably positioned in said slots to slide in and out of said slots so as to seal with the cavity'"'"'s internal sidewall creating vane chambers that pump dialysate through said dialysate flow path;

a second pump including a second pump motor and a second pump actuator connected to said dialysate flow path upflow from said dialyzer for pumping dialysate through said dialysate flow path, said second pump actuator including a sliding vane construction having non-deformable components including a housing having a central cavity forming an internal sidewall, a rotor eccentrically positioned within said cavity and said rotor having a plurality of radially aligned slots at said rotor'"'"'s periphery, vanes slideably positioned in said slots to slide in and out of said slots so as to seal with the cavity'"'"'s internal sidewall creating vane chambers that pump dialysate through said dialysate flow path; and

a third pump including a third pump motor and a third pump actuator connected to said blood flow path for pumping blood through said blood flow path, said third pump actuator including a sliding vane construction having non-deformable components including a housing having a central cavity forming an internal sidewall, a rotor eccentrically positioned within said cavity and said rotor having a plurality of radially aligned slots at said rotor'"'"'s periphery, vanes slideably positioned in said slots to slide in and out of said slots so as to seal with the cavity'"'"'s internal sidewall creating vane chambers that pump blood through said blood flow path; and

a processor connected to said first, second and third pump motors for controlling operation of said pump motors.

2. The hemodialysis system of claim 1 further comprising:

a reusable dialysis machine and a disposable cartridge wherein said disposable cartridge is connectable and disconnectable to said reusable dialysis machine; and

said first, second and third pump motors are positioned with said reusable dialysis machine and said first, second and third pump actuators are positioned with said disposable cartridge.

3. The hemodialysis system of claim 1 wherein dialyzer includes a semipermeable membrane that separates said blood flow path and said dialysate flow path and said processor monitors said pressure sensors and controls said pump motors so as to maintain a predetermined pressure differential across said semipermeable membrane.

4. The hemodialysis system of claim 3 wherein said processor maintains said pressure differential within the dialyzer of the blood flow path relative to dialysate flow path at about zero.

5. The hemodialysis system of claim 3 wherein said processor maintains said pressure differential within the dialyzer of the blood flow path relative to dialysate flow path above zero to provide ultrafiltration.

6. The hemodialysis system of claim 1 wherein said first, second and third pump motors are electric rotary motors.