Methods for reducing the blood priming volume and membrane surface area in microfluidic lung assist devices
First Claim
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1. A microfluidic oxygenation device comprising:
- a first polymer layer defining a first oxygen flow channel therein;
a second polymer layer defining a first blood flow channel therein, the first blood flow channel overlapping the first oxygen flow channel, and the first blood flow channel further comprising a plurality of passive mixing elements spaced sequentially along a length of a first wall of the first blood flow channel, wherein the plurality of passive mixing elements have a height or a depth less than about 30% of a height of the first blood flow channel and are configured to redistribute a fluid flowing through the first blood flow channel within the channel; and
a membrane separating the first oxygen flow channel and the first blood flow channel at the overlapping portions of the channels, the membrane allowing communication between the first oxygen flow channel and the first blood flow channel.
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Abstract
A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices.
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Citations
19 Claims
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1. A microfluidic oxygenation device comprising:
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a first polymer layer defining a first oxygen flow channel therein; a second polymer layer defining a first blood flow channel therein, the first blood flow channel overlapping the first oxygen flow channel, and the first blood flow channel further comprising a plurality of passive mixing elements spaced sequentially along a length of a first wall of the first blood flow channel, wherein the plurality of passive mixing elements have a height or a depth less than about 30% of a height of the first blood flow channel and are configured to redistribute a fluid flowing through the first blood flow channel within the channel; and a membrane separating the first oxygen flow channel and the first blood flow channel at the overlapping portions of the channels, the membrane allowing communication between the first oxygen flow channel and the first blood flow channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for oxygenating deoxygenated blood, the method comprising:
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providing a microfluidic device comprising a first polymer layer defining a first oxygen flow channel;
a second polymer layer defining a first blood flow channel, the first blood flow channel further comprising a plurality of passive mixing elements spaced sequentially along a length of a surface of the first blood flow channel, wherein the plurality of passive mixing elements have a height or a depth less than about 30% of a height of the first blow flow channel; and
a membrane separating the first oxygen flow channel and the first blood flow channel, the membrane allowing communication between the first oxygen flow channel and the first blood flow channel;introducing partially deoxygenated blood into a proximal end of the microfluidic device; flowing oxygen through the first oxygen flow channel; flowing the partially deoxygenated blood through the first blood flow channel; and receiving oxygenated blood at a distal end of the microfluidic device. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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Specification