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Methods for reducing the blood priming volume and membrane surface area in microfluidic lung assist devices

  • US 9,180,239 B2
  • Filed: 12/05/2012
  • Issued: 11/10/2015
  • Est. Priority Date: 12/05/2011
  • Status: Active Grant
First Claim
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1. A microfluidic oxygenation device comprising:

  • a first polymer layer defining a first oxygen flow channel therein;

    a second polymer layer defining a first blood flow channel therein, the first blood flow channel overlapping the first oxygen flow channel, and the first blood flow channel further comprising a plurality of passive mixing elements spaced sequentially along a length of a first wall of the first blood flow channel, wherein the plurality of passive mixing elements have a height or a depth less than about 30% of a height of the first blood flow channel and are configured to redistribute a fluid flowing through the first blood flow channel within the channel; and

    a membrane separating the first oxygen flow channel and the first blood flow channel at the overlapping portions of the channels, the membrane allowing communication between the first oxygen flow channel and the first blood flow channel.

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