Laboratory animal pulmonary dosing device
First Claim
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1. A laboratory animal pharmaceutical testing device comprising a substantially closed animal holding cell sized to accommodate more than one animal at the same time;
- a vibratory dry powder generator communicating through an opening in a wall of the cell for introduction of a medication into the cell;
one or more filtered inlets for permitting exchange of fresh air into the cell; and
a conduit including a fan through which air and medication in the cell is recirculated out of the cell and returned to the cell;
wherein the opening in the wall of the cell through which the medication is introduced into the cell is located in an upper part of the cell so that the bulk of the medication will be inhaled by the animals before the medication settles in the bottom of the cell, andwherein said cell and conduit are sealed such that air and nebulized medication inside the cell or conduit are not able to exit from the cell and conduit to the atmosphere outside of the cell and conduit.
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Abstract
A laboratory animal pharmaceutical testing device comprising a substantially closed animal holding cell, having a dry powder generator communicating through a wall of the cell, and one or more filtered inlets for permitting exchange of fresh air into the cell.
101 Citations
23 Claims
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1. A laboratory animal pharmaceutical testing device comprising a substantially closed animal holding cell sized to accommodate more than one animal at the same time;
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a vibratory dry powder generator communicating through an opening in a wall of the cell for introduction of a medication into the cell; one or more filtered inlets for permitting exchange of fresh air into the cell; and a conduit including a fan through which air and medication in the cell is recirculated out of the cell and returned to the cell; wherein the opening in the wall of the cell through which the medication is introduced into the cell is located in an upper part of the cell so that the bulk of the medication will be inhaled by the animals before the medication settles in the bottom of the cell, and wherein said cell and conduit are sealed such that air and nebulized medication inside the cell or conduit are not able to exit from the cell and conduit to the atmosphere outside of the cell and conduit. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A device for delivering dry powder medication to laboratory animals, comprising an aerosol chamber into which an aerosolized medication may be introduced;
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an animal holding cell including a mask portion, wherein said animal holding cell is sized to restrain an animal'"'"'s mouth and nose in position within the cell and wherein the mask portion includes a mouthpiece or nasal cannula; an outlet for said chamber in communication with said animal holding cell, wherein said outlet is at least partially surrounded by said mask portion; a nebulizer for aerosolizing a medication and introducing the medication into the chamber; a sensor for sensing an inhalation and/or exhalation cycle of the animal, and a controller for turning the nebulizer on and off synchronized to tidal breathing of the animal, and an exhaust fan, a filter, a scrubber and a dryer in communication with the aerosol chamber and also in communication with atmospheric air outside the device, wherein air carrying the aerosolized medication passes through the exhaust fan, filter, scrubber and dryer before being vented into the outside atmospheric air so that loss of medication from the device is minimized; and
a conduit including the fan through which air and medication in the cell is recirculated out of the cell and returned to the cell. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A laboratory animal pharmaceutical testing device comprising at least one animal holding chamber sized to restrain a laboratory animal with its mouth and nose held in position;
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a first chamber and a second chamber, wherein said first chamber and said second chamber are each in communication with said holding chamber; a pharmaceutical nebulizer communicating through said first chamber to said holding chamber; a controller for controlling the nebulizer; a sensor for sensing an inhalation and/or exhalation cycle of the animal, and a controller for turning the nebulizer on and off synchronized to tidal breathing of the animal; a pressurized air source in communication with the nebulizer and capable of producing a positive pressure air stream to deliver a medication from the nebulizer to the mask or nasal cannula section; and an exhaust fan, a filter, a scrubber and a dryer in communication with an outlet in said second chamber and also in communication with atmospheric air outside the device, wherein air carrying the medication passes through the exhaust fan, filter, scrubber and dryer before being vented into the outside atmospheric air so that loss of medication from the device is minimized; and
a conduit including the fan through which air and medication in the cell is recirculated out of the at least one animal holding chamber and returned to the cell. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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Specification