System for transporting fluid across or into a biological barrier, device and capsule as part of the system

• US 9,180,283 B2
• Filed: 09/21/2012
• Issued: 11/10/2015
• Est. Priority Date: 09/23/2011
• Status: Active Grant

• Current Assignee: Ambro B.V.
• Original Assignee: Ambro B.V.
• Inventors: Brouwers, Arnoldus Maria, Brouwers, Bouke Jan
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): LANDRY II, GERALD ERNEST
• Application Number:
  US14/346,425
• Publication Number:
  US 20140236089A1
• Time in Patent Office: 1,145 Days
• Field of Search: 604/173, 604/272
• US Class Current: 1/1
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

The invention relates to a system (1) for transporting fluid across or into a biological barrier, the system comprises a device (10) having a housing with at least one abutment surface for abutting the biological barrier. A capsule is to be received in the housing comprising a substrate (21) from which a plurality of hollow micro needles (22) project and a fluid reservoir (26) which can be brought into fluid communication with the micro needles. According to the invention the capsule comprises a fluid dose and the device comprises a ram (12) arranged movably in the housing for pushing the capsule from a first position to a second position. The ram subsequently proceeds to a third ram position thereby deforming the reservoir for raising the pressure inside the reservoir such that the fluid dose will be transported through the hollow micro needles across or into the biological barrier.

Claims

1. A system for transporting fluid across or into a biological barrier, which system comprises:

a device that is provided with a housing having at least one abutment surface for abutting the biological barrier;

a substrate from which a plurality of hollow micro needles project, which substrate is to be received in the housing;

a fluid reservoir which can be brought into fluid communication with the micro needles;

which reservoir is to be received in the housing;

wherein the device comprises a displacement mechanism that comprises a ram arranged movably in the housing from a first to a second ram position in a direction that is substantially perpendicular to the abutment surface for displacing the substrate and the reservoir relative to the abutment surface from a first position, in which the micro needles essentially are present in the housing, to a second position from which the micro needles project out of the housing beyond the abutment surface, such that they can penetrate the biological barrier, wherein the reservoir and the substrate are incorporated into a capsule to be inserted in the housing, said capsule being an enclosure comprising a fluid dose,-the housing comprises an end part for receiving the capsule, the abutment surface being provided on the end part, the ram is arranged to displace the capsule by pushing the capsule from the first position to the second position in the end part, and in that the ram subsequently proceeds to a third ram position thereby deforming the reservoir for raising the pressure inside the reservoir such that the fluid dose will be transported through the hollow micro needles across or into the biological barrier substantially all at a time.

2. A system according to claim 1, wherein the displacement mechanism further comprises pre-tensioning means for pre-tensioning the ram in an initial position.

3. A system according to claim 2, wherein the displacement mechanism further comprises an eccentrical drive for releasing the pre-tensioning means.

4. A system according to claim 1, wherein the housing comprises a stop member and wherein the reservoir or the substrate comprises at least one shoulder, which shoulder rests against the stop member in the second position.

5. A system according to claim 1, wherein the material of the reservoir is deformable.

6. A system according to claim 5, wherein the reservoir is generally dome shaped and the dome comprises a contact area for the ram.

7. A system according to claim 1, wherein the capsule is intended for one time use only.

8. A system according to claim 7, wherein a skin stretching ring also forms part of the capsule, wherein the reservoir and the substrate are mounted for displacement relative to the skin stretching ring.

9. A device for transporting fluid across or into a biological barrier that is provided with a housing having at least one abutment surface for abutting the biological barrier, wherein the device comprises a displacement mechanism that comprises a ram arranged movably in the housing from a first to a second ram position in a direction that is substantially perpendicular to the abutment surface, characterised in that the housing comprises an end part for receiving a capsule to be inserted in the housing, said capsule being an enclosure comprising a fluid dose, the abutment surface being provided on the end part, the ram is arranged to displace the capsule by pushing the capsule from the first position to the second position in the end part, and in that the ram subsequently proceeds to a third ram position thereby deforming the capsule for raising the pressure inside the reservoir such that the fluid dose will be transported across or into the biological barrier substantially all at a time.

10. A capsule-comprising a substrate from which a plurality of hollow micro needles project and a fluid reservoir which can be brought into fluid communication with the micro needles, said capsule being an enclosure comprising a fluid dose.