Morpholine-spirocyclic piperidine amides as modulators of ion channels
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Abstract
The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
23 Citations
21 Claims
- 1. A compound of formula I:
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20. The method of 19, wherein said method is used for treating or lessening the severity of femur cancer pain;
- non-malignant chronic bone pain;
rheumatoid arthritis;
osteoarthritis;
spinal stenosis;
neuropathic low back pain;
neuropathic low back pain;
myofascial pain syndrome;
fibromyalgia;
temporomandibular joint pain;
chronic visceral pain, abdominal pain;
pancreatic;
IBS pain;
chronic and acute headache pain;
migraine;
tension headache, including, cluster headaches;
chronic and acute neuropathic pain, post-herpatic neuralgia;
diabetic neuropathy;
HIV-associated neuropathy;
trigeminal neuralgia;
Charcot-Marie Tooth neuropathy;
hereditary sensory neuropathies;
peripheral nerve injury;
painful neuromas;
ectopic proximal and distal discharges;
radiculopathy;
chemotherapy induced neuropathic pain;
radiotherapy-induced neuropathic pain;
post-mastectomy pain;
central pain;
spinal cord injury pain;
post-stroke pain;
thalamic pain;
complex regional pain syndrome;
phantom pain;
intractable pain;
acute pain, acute post-operative pain;
acute musculoskeletal pain;
joint pain;
mechanical low back pain;
neck pain;
tendonitis;
injury/exercise pain;
acute visceral pain, abdominal pain;
pyelonephritis;
appendicitis;
cholecystitis;
intestinal obstruction;
hernias;
chest pain, cardiac pain;
pelvic pain, renal colic pain, acute obstetric pain, labor pain;
cesarean section pain;
acute inflammatory, burn and trauma pain;
acute intermittent pain, endometriosis;
acute herpes zoster pain;
sickle cell anemia;
acute pancreatitis;
breakthrough pain;
orofacial pain including sinusitis pain, dental pain;
multiple sclerosis (MS) pain;
pain in depression;
leprosy pain;
Behcet'"'"'s disease pain;
adiposis dolorosa;
phlebitic pain;
Guillain-Barre pain;
painful legs and moving toes;
Haglund syndrome;
erythromelalgia pain;
Fabry'"'"'s disease pain;
bladder and urogenital disease, including, urinary incontinence;
hyperactivity bladder;
painful bladder syndrome;
interstitial cyctitis (IC);
prostatitis;
complex regional pain syndrome (CRPS), type I and type II;
widespread pain, paroxysmal extreme pain, pruritis, tinnitis, or angina-induced pain.
- non-malignant chronic bone pain;
Specification