Methods and systems for photoacoustic monitoring using hypertonic and isotonic indicator dilutions
First Claim
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1. A system for determining a value of the physiological parameter of a subject, the system comprising:
- a light source configured to provide a photonic signal to a first blood vessel site of the subject;
an acoustic detector configured to detect an acoustic pressure signal from the first blood vessel site, wherein the acoustic pressure signal is caused by absorption of at least some of the photonic signal by one or more constituents at the first blood vessel site, and wherein the acoustic pressure signal comprises;
a first acoustic pressure response based on an isotonic indicator provided to a second blood vessel site at a first time, anda second acoustic pressure response based on a hypertonic indicator provided to the second blood vessel site at a second time, wherein the first time and the second time are during the same clinical session; and
processing equipment configured to determine a value of the physiological parameter of the subject based on the first response and the second response.
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Abstract
A patient monitoring system may provide photoacoustic sensing based on an indicator dilution to determine one or more physiological parameters of a subject. The system may detect an acoustic pressure signal, which may include one or more thermo-dilution responses, one or more hemo-dilution responses, or a combination thereof. For example, a thermo-dilution indicator and/or a hemo-dilution indicator may be used to determine one or more hemodynamic parameters. In a further example, an isotonic indicator and a hypertonic indicator may be used to determine one or more hemodynamic parameters of the subject.
36 Citations
21 Claims
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1. A system for determining a value of the physiological parameter of a subject, the system comprising:
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a light source configured to provide a photonic signal to a first blood vessel site of the subject; an acoustic detector configured to detect an acoustic pressure signal from the first blood vessel site, wherein the acoustic pressure signal is caused by absorption of at least some of the photonic signal by one or more constituents at the first blood vessel site, and wherein the acoustic pressure signal comprises; a first acoustic pressure response based on an isotonic indicator provided to a second blood vessel site at a first time, and a second acoustic pressure response based on a hypertonic indicator provided to the second blood vessel site at a second time, wherein the first time and the second time are during the same clinical session; and processing equipment configured to determine a value of the physiological parameter of the subject based on the first response and the second response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 21)
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12. A system for determining a value of a physiological parameter of a subject, the system comprising:
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a light source configured to provide a photonic signal to a site of a pulmonary artery or an aorta of a subject; one or more acoustic detectors configured to detect an acoustic pressure signal from the site of the pulmonary artery or the aorta of the subject, wherein the acoustic pressure signal is caused by the absorption of a portion of the photonic signal by the pulmonary artery or the aorta, and wherein the acoustic pressure signal comprises; a first acoustic pressure response based on an isotonic indicator provided to a site of a vein of the subject at a first time, and a second acoustic pressure response based on a hypertonic indicator provided to the site of the vein of the subject at a second time, wherein the first time and the second time are during the same clinical session; and processing equipment configured to determine a value of the physiological parameter of the subject based on the first response and the second response. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification