Methods of treating pains associated with neuroma, nerve entrapment, and other conditions

• US 9,186,273 B2
• Filed: 05/04/2010
• Issued: 11/17/2015
• Est. Priority Date: 05/04/2009
• Status: Expired due to Fees

• Current Assignee: Nuvo Pharmaceuticals Inc. (Searchlight Pharma, Inc.)
• Original Assignee: Nuvo Research AG (Searchlight Pharma, Inc.)
• Inventors: Zhang, Jie, Lippert, Robert
• Primary Examiner(s): RICCI, CRAIG D
• Application Number:
  US12/773,239
• Publication Number:
  US 20110112189A1
• Time in Patent Office: 2,023 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61F 2007/0071 using a resistor, e.g. near the spot to be heated
• CPC Class Codes: A61F 2007/0261 medicated
• CPC Class Codes: A61F 2007/0292 using latent heat produced or absorbed during phase change of materials, e.g. of super-cooled solutions
• CPC Class Codes: A61F 7/02 Compresses or poultices for effecting heating or cooling
• CPC Class Codes: A61F 7/03 thermophore, i.e. self-heating, e.g. using a chemical reaction
• CPC Class Codes: A61F 7/034 Flameless
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/245 Amino benzoic acid types, e.g. procaine, novocaine salicylic acid esters A61K31/60
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 23/02 Local anaesthetics
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/02 for peripheral neuropathies
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present disclosure is drawn to methods for treating various types of pain. Specifically, a method for treating various types of pain includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36° C. to 42° C.

Claims

1. A method for treating connective tissue pain, comprising:

a) applying an integrated analgesic system to a skin surface of a subject experiencing connective tissue pain, said analgesic system, comprising;

i) a heating device configured to heat the skin surface to a temperature of 35°

C. to 47°

C., and

ii) a local anesthetic formulation including a eutectic mixture of lidocaine and tetracaine, wherein the local anesthetic formulation is applied to the skin surface over the existing pain;

b) heating the skin surface to a temperature of 35°

C. to 47°

C.; and

c) maintaining the analgesic system on the skin surface for a period of time of at least 2 hours.

2. The method of claim 1, wherein the heating device begins heating at about the same time as the analgesic system is applied to the skin surface.

3. The method of claim 1, wherein the weight percentage of the eutectic mixture is at least 30 wt % of the local anesthetic formulation.

4. The method of claim 1, wherein the local anesthetic formulation has a skin contact region having an area of 2 cm² to 200 cm².

5. The method of claim 1, wherein the local anesthetic formulation has a skin contact region having an area of 7 cm² to 150 cm².

6. The method of claim 1, wherein the local anesthetic formulation has a skin contact region, said skin contact region having an area of 8 cm² to 15 cm².

7. The method of claim 1, wherein the connective tissue pain is ligament pain.

8. The method of claim 1, wherein the connective tissue pain is tendon pain.

9. The method of claim 1, wherein the connective tissue pain is iliotibial band pain.

10. The method of claim 1, wherein the connective tissue pain is associated with a blood vessel.

11. The method of claim 8, wherein the connective tissue pain is caused by tendinopathy.

12. The method of claim 11, wherein the tendinopathy is clavicular or patellar tendonitis.

13. The method of claim 11, wherein the tendinopathy is tennis elbow.

14. The method of claim 11, wherein the tendinopathy is medial tibial stress syndrome.

15. The method of claim 1, wherein the heating device is configured to generate heat by an exothermic oxidative chemical reaction.

16. The method of claim 1, wherein the skin surface is heated to a temperature of 36°

C. to 42°

C.

17. The method of claim 1, wherein the skin surface is heated to a temperature of 38°

C. to 42°

C.

18. The method of claim 1, wherein the skin surface is heated to a temperature of 36°

C. to 40°

C.

19. The method of claim 1, further comprising removing the analgesic system after the period of at least two hours, wherein after removal of the analgesic system, the subject experiences relief of the connective tissue pain for a period of at least 4 hours.

20. The method of claim 1, further comprising removing the analgesic system after the period of at least two hours, wherein after removal of the analgesic system, the subject experiences relief of the connective tissue pain for a period of at least 6 hours.

21. The method of claim 1, further comprising removing the analgesic system after the period of at least two hours, wherein after removal of the analgesic system, the subject experiences relief of the connective tissue pain for a period of at least 12 hours.