Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds

• US 9,186,297 B2
• Filed: 05/03/2013
• Issued: 11/17/2015
• Est. Priority Date: 09/12/2005
• Status: Active Grant

• Current Assignee: Abela Pharmaceuticals, Inc.
• Original Assignee: Abela Pharmaceuticals, Inc.
• Inventors: Claussen, Harvey L., Cozean, Colette, De La Torre, Jack
• Primary Examiner(s): MARCETICH, ADAM M
• Application Number:
  US13/887,206
• Publication Number:
  US 20140058337A1
• Time in Patent Office: 928 Days
• US Class Current: 1/1
• CPC Class Codes: A61J 1/00 Containers specially adapted for medical or pharmaceutical purposes capsules or the like for oral use A61J3/07; specially adapted for surgical or diagnostic appliances or instruments A61B50/30; containers for radioactive substances G21F5/00
• CPC Class Codes: A61J 1/18 Arrangements for indicating condition of container contents, e.g. sterile condition
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: B32B 27/18 characterised by the use of special additives
• CPC Class Codes: B32B 27/20 using fillers, pigments, thixotroping agents
• CPC Class Codes: B65D 55/026 initial opening or unauthorised access being indicated by a visual change using indicators other than tearable means, e.g. change of colour, pattern or opacity B65D55/066 takes precedence
• CPC Class Codes: B65D 79/02 Arrangements or devices for indicating incorrect storage or transport B65D79/005 takes precedence ; measuring devices G01
• CPC Class Codes: G01M 3/04 by detecting the presence of fluid at the leakage point
• CPC Class Codes: G01M 3/042 by using materials which expand, contract, disintegrate, or decompose in contact with a fluid G01M3/12 takes precedence

Abstract

The invention relates generally to materials for facilitating the administration of dimethyl sulfoxide (DMSO) and related compounds. In one embodiment, the invention comprises a kit comprising items used for the safe and effective administration of DMSO. In another embodiment, the invention relates to indicating containers for holding or delivering DMSO.

Claims

1. An intravenous (IV) bag for holding or delivering dimethyl sulfoxide (DMSO), comprising:

an inner layer, wherein the inner layer is fluid resistant and wherein in the inner layer is a material that is insoluble in DMSO;

an outer protective layer;

an intermediate binding layer comprising a binding material that contacts said inner and said outer layer; and

an indicator layer positioned between the inner layer and the intermediate layer, wherein said indicator layer is configured to indicate that dimethyl sulfoxide (DMSO) and/or a related compound has escaped from the inner layer.

2. The IV bag of claim 1, wherein the IV bag is configured to hold or deliver an IV solution having DMSO at levels from trace amounts to 100% DMSO.

3. The IV bag of claim 2, wherein the IV bag is configured to hold or deliver an IV solution having DMSO at levels from 5% to 30% DMSO.

4. The IV bag of claim 1, wherein the indicator layer comprises a light transmission changing indicator.

5. The IV bag of claim 4, wherein the light transmission changing indicator comprises a DMSO-absorptive plastic.

6. The IV bag of claim 5, wherein the DMSO-absorptive plastic turns from clear to cloudy or from transparent to translucent upon exposure to DMSO, thereby visually indicating that DMSO and/or a related compound has escaped from the inner layer.

7. The IV bag of claim 1, wherein the indicator layer comprises a color changing indicator.

8. The IV bag of claim 7, wherein the color changing indicator comprises a compound that changes color upon exposure to moisture related to the escape of DMSO and/or a related compound from the inner layer.

9. The IV bag of claim 1, wherein the indicator layer comprises a coating or dusting of indicator particles between the inner and the intermediate layer.

10. The IV bag of claim 1, wherein the intermediate layer comprises a polyamide film that binds the inner and the outer layer.

11. The IV bag of claim 1, wherein the outer layer comprises a thermoplastic polymer.

12. The IV bag of claim 1, wherein the IV bag is prepared by co-extrusion.

13. A kit for facilitating the administration of dimethyl sulfoxide (DMSO) comprising:

a) a container for holding or delivering dimethyl sulfoxide (DMSO) comprising;

an inner layer, wherein the inner layer is fluid resistant and wherein the inner layer is a material that is insoluble in dimethyl sulfoxide (DMSO);

a protective outer layer;

an intermediate binding layer comprising a binding material that binds the inner and the outer layers; and

an indicator layer disposed between the inner layer and the intermediate layer and configured to indicate whether DMSO and/or a related compound has escaped from the inner layer;

b) at least one DMSO resistant catheter;

c) at least one DMSO resistant needle; and

d) instructions for use.

14. The kit of claim 13, further comprising DMSO.

15. The kit of claim 13, further comprising an adsorbant material for adsorbing odors associated with DMSO and/or related compounds.

16. The kit of claim 13, wherein the kit is for treating a patient in need of neuroprotective and/or neurotherapeutic treatment.