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Hot melt TTS for administering rotigotine

  • US 9,186,335 B2
  • Filed: 07/29/2003
  • Issued: 11/17/2015
  • Est. Priority Date: 07/30/2002
  • Status: Active Grant
First Claim
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1. A transdermal therapeutic system comprising a drug-containing adhesive matrix, wherein the drug-containing adhesive matrix comprises:

  • a solidified melt comprising rotigotine free-base present in an amount of 1-40 weight % with a purity level above 98% anda hot-melt adhesive present in an amount of 50-99 weight % ,wherein the drug-containing adhesive matrix exhibits at 160°

    C. a dynamic viscosity of not more than 100 Pa·

    s andwherein the drug-containing adhesive matrix is produced by metering the rotigotine free-base into a solvent-free melt at a temperature of between 70°

    C. and 200°

    C.

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