Split dose administration
First Claim
1. A method for producing an increased level of erythropoietin (EPO) in a mammalian subject, comprising(a) administering to said subject a total daily dose of an mRNA encoding erythropoietin (EPO) in two or more equal or unequal split doses within a 24 hour period, wherein said mRNA comprises SEQ ID NO:
- 9; and
(b) determining that the level of erythropoietin (EPO) in a bodily fluid of said subject is greater than the level produced by administering the same total daily dose as a single administration.
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Accused Products
Abstract
The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell'"'"'s function and/or activity.
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Citations
9 Claims
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1. A method for producing an increased level of erythropoietin (EPO) in a mammalian subject, comprising
(a) administering to said subject a total daily dose of an mRNA encoding erythropoietin (EPO) in two or more equal or unequal split doses within a 24 hour period, wherein said mRNA comprises SEQ ID NO: - 9; and
(b) determining that the level of erythropoietin (EPO) in a bodily fluid of said subject is greater than the level produced by administering the same total daily dose as a single administration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 9; and
Specification