Extracellular matrix composite materials, and manufacture and use thereof
First Claim
1. A medical graft material, comprising an extracellular matrix composite including a first naturally derived extracellular matrix material having a surface, and a second, biosynthetically-deposited extracellular matrix material on said surface, wherein the second extracellular matrix material is secreted by cells onto the first extracellular matrix material, wherein the second, biosynthetically-deposited extracellular matrix material is secreted by cells which are xenogenic to the first extracellular matrix material wherein the second extracellular matrix material contains extracellular matrix components that are exogenous with respect to the first extracellular matrix material, and wherein said medical graft material is free of living cells.
2 Assignments
0 Petitions
Accused Products
Abstract
Described are preferred extracellular matrix composites including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components on the material. The cells are then removed to provide the extracellular matrix composite material.
-
Citations
28 Claims
- 1. A medical graft material, comprising an extracellular matrix composite including a first naturally derived extracellular matrix material having a surface, and a second, biosynthetically-deposited extracellular matrix material on said surface, wherein the second extracellular matrix material is secreted by cells onto the first extracellular matrix material, wherein the second, biosynthetically-deposited extracellular matrix material is secreted by cells which are xenogenic to the first extracellular matrix material wherein the second extracellular matrix material contains extracellular matrix components that are exogenous with respect to the first extracellular matrix material, and wherein said medical graft material is free of living cells.
-
16. An extracellular matrix graft prosthesis conditioned with matrix components, comprising:
-
an extracellular matrix graft material; and biosynthetically-deposited exogenous extracellular matrix components on said extracellular matrix graft material, wherein the exogenous extracellular matrix components are secreted by cells onto the extracellular matrix graft material, and wherein said graft prosthesis is free of living cells and in a dried condition, and wherein said medical graft prosthesis is packaged in a sterile sealed package. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
Specification