Electronically assisted drug delivery device

• US 9,186,465 B2
• Filed: 11/05/2009
• Issued: 11/17/2015
• Est. Priority Date: 11/06/2008
• Status: Active Grant

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Ludvigsen, Henrik Groth, Hansen, Michael Ejstrup, Beyerholm, Erik, Elahi, Ramin Nateghi, Jrgensen, Bjarke Dupont, Petersen, Jan Lindhardt, Linnebjerg, Steven
• Primary Examiner(s): Stigell, Theodore
• Application Number:
  US13/126,378
• Publication Number:
  US 20110270214A1
• Time in Patent Office: 2,203 Days
• Field of Search: 604207-211
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 2005/3152 including gearings to multiply or attenuate the piston displacing force
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31543 piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31558 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/31575 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button

Abstract

The present invention relates to electronically assisted drug delivery devices (100). The drug delivery device may include a Gray code type detector for sensing dosage data, wherein the detector comprises a code track consisting of a sequence of alternating markings and a plurality of detectors that are mutually spaced in a direction extending along the code track. The drug delivery device may also include a dosage selector (260) which is moved in a proximal direction upon dose setting and in a distal direction upon dose injection, where the dosage selector is latched in the end of dose position by a latching element, the latching element actuating an end of dose switch for signalling the end of dose state. The drug delivery device may also incorporate power-management arrangements which effectively minimizes power consumption for the incorporated electronic circuitry.

Claims

1. A drug delivery device for setting and injecting set doses of a drug from a drug-filled reservoir comprising a Gray code type detector for detecting relative movement between a first element and a second element during dose setting and/or during injection, said Gray code type detector comprising:

a plurality of alternating first and second areas disposed on said first element, wherein said first and second areas are configured to first and second states, respectively, and wherein each of said first areas comprise width X₁ and each of said second areas comprise width X₂, and

wherein a plurality of detectors comprises m detectors, wherein m is at least three wherein each of the m detectors is disposed on said second element and is configured to sense said first and second states

wherein said detectors are arranged in a direction respective to said first and second areas'"'"' longitude so as to sense said first and second states and provide a reading sequence of a Gray code scheme when said detectors are moved relatively to said first and second areas.

2. A drug delivery device as in claim 1, wherein said plurality of alternating first and second areas disposed on said first element is arranged as a circumferential band on a cylindrical surface, either on an interior cylindrical surface or an external cylindrical surface.

3. A drug delivery device as in claim 1, wherein said first element includes at least one additional area adapted to be sensed by one or more additional detector(s), said additional detector(s) being arranged on the second element for sensing movements relative to said plurality of alternating first and second areas in directions transverse to the direction along said Gray code scheme.

4. A drug delivery device as in claim 3, wherein said drug delivery device includes a dose setting member and an injection button, wherein rotational movements of said dose setting member is detected by said Gray code type detector, and wherein said additional detector(s) are configured to detect whether or not an injection force is applied to said injection button.

5. A drug delivery device as in claim 1, wherein said plurality of alternating first and second areas includes areas of electrical conducting and electrical non-conducting materials, respectively, and wherein said at least three detectors are contact switches arranged to electronically sense the presence or absence of an electrical conducting material.

6. A drug delivery device as in claim 1, wherein said at least three detectors forms a reading assembly for detecting relative rotational position changes between said first element and said second element during dose setting and/or during dose injection, and wherein said plurality of alternating first and second areas to encircle said reading assembly.

7. A drug delivery device as in claim 1, wherein said plurality of alternating first and second areas is arranged as a helically extending track.

8. A drug delivery device as in claim 1, wherein said plurality of alternating first and second areas and said at least three detectors forms a single Gray code scheme or a multitude of repeated Gray code schemes forming a total scheme code length n.

9. A drug delivery device as in claim 8, wherein said detectors are contact switches.

10. A drug delivery device as in claim 9, wherein at least one of said contact switches is closed upon at least every other state change in either direction from a present position, said present position being selected from any of each possible n position.

11. A drug delivery device as in claim 8, wherein said drug delivery device includes a rotatable dosage selector associated with said second element and being rotatable in a number of distinct rotational positions P spanning a single revolution, wherein said Gray code type detector is configured for detecting rotational position of said dosage selector and wherein said total scheme length n is selected as two, three or four times P.

12. A drug delivery device as in claim 1, wherein said at least three detectors comprise three, four, five, six or seven detectors.