Implantable delivery device system for delivery of a medicament to a bladder

• US 9,186,489 B2
• Filed: 03/10/2014
• Issued: 11/17/2015
• Est. Priority Date: 03/27/2003
• Status: Active Grant

• Current Assignee: Coloplast A/S
• Original Assignee: Coloplast A/S
• Inventors: Browning, James
• Primary Examiner(s): Palenik, Jeffrey T
• Application Number:
  US14/201,962
• Publication Number:
  US 20140188042A1
• Time in Patent Office: 617 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 6/02 for use by males A61F6/20 takes precedence
• CPC Class Codes: A61F 6/06 for use by females A61F6/20 takes precedence
• CPC Class Codes: A61F 6/142 Wirelike structures, e.g. loops, rings, spirals
• CPC Class Codes: A61K 9/0036 Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
• CPC Class Codes: A61K 9/0039 Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 31/028 Other inorganic materials not covered by A61L31/022 - A61L31/026
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/043 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2205/04 implanted
• CPC Class Codes: A61M 31/007 Injectors for solid bodies, e.g. suppositories
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

An implantable delivery device system for delivery of a medicament to a bladder includes a device body, a drug coating disposed over at least a portion of the device body, and an insertion tool. The device body includes a first end and a second end opposite of the first end, the first end having a first diameter and including a sharp tip for penetrating tissue and the second end having a second diameter and including a head portion. The second diameter is larger than the first diameter. The drug coating is disposed over a portion of the device body and is provided for treatment of an over active bladder. The insertion tool has a shaft located between a proximal end of the tool that includes a handle shaft and a distal end of the tool that is attachable to the head of the device.

Claims

1. An implantable delivery device system for delivery of a medicament to a bladder, the device comprising:

a device body including a first end and a second end opposite of the first end, the first end having a first diameter and including a sharp tip for penetrating tissue and the second end having a second diameter and including a head portion, the second diameter is larger than the first diameter;

a drug coating disposed over at least a portion of the device body, wherein the drug coating is provided for treatment of an over active bladder with controlled delivery of a drug over a duration of time; and

an insertion tool, the insertion tool comprising a shaft located between a proximal end of the tool that includes a handle shaft and a distal end of the tool that is attachable to the head of the device.

2. The system of claim 1, wherein the device body includes a retrieval mechanism.

3. The system of claim 1, wherein the drug coating includes an anti-cholinergic drug.

4. The system of claim 1, wherein the drug coating includes a calcium antagonist.

5. The system of claim 1, wherein the drug coating includes an agent for radiotherapy.

6. The system of claim 1, wherein the device body is absorbable.

7. An implantable delivery device system for treatment of a bladder, the device comprising:

a device body including a first end and a second end opposite of the first end, the first end having a first diameter and including a sharp tip configured to penetrate tissue of the bladder and the second end having a second diameter and including a head portion, the second diameter is larger than the first diameter;

a medicament disposed over at least a portion of the device body, wherein the medicament is selected to treat the bladder through a controlled delivery of a therapeutic agent over a duration of time; and

an insertion tool, the insertion tool comprising a shaft located between a proximal end of the tool that includes a handle shaft and a distal end of the tool that is attachable to the head of the device.

8. The system of claim 7, wherein the device body includes a retrieval mechanism.

9. The system of claim 7, wherein the medicament is selected to treat an over active bladder.

10. The system of claim 9, wherein the medicament includes an anti-cholinergic drug.

11. The system of claim 9, wherein the medicament includes a calcium antagonist.

12. The system of claim 9, wherein the medicament includes an agent for radiotherapy.

13. The system of claim 7, wherein the therapeutic agent is selected from the group consisting of anti-infectives, antimicrobials, prebiotics, probiotics, acidifiers, antivirals, antibiotics, anti-allergenics, anti-inflammatories, anti-fungals, anticholinesterases, and chemotherapeutic agents.

14. The system of claim 7, wherein the head portion is configured for manipulation and surveillance of the device body.