Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
First Claim
1. An apparatus for treating a neural condition of a patient, comprising:
- an implantable stimulation lead configured to be positioned to apply electrical stimulation to neural tissue of the patient'"'"'s nervous system, the implantable stimulation lead configured to be implanted in the patient; and
an implantable signal generator for generating electrical pulses, the implantable signal generator coupled to the implantable stimulation lead, wherein the implantable signal generator comprises a controller;
wherein the controller is configured to direct an application of electrical stimulation to the patient in a manner such that the stimulation has a burst frequency and an intra-burst frequency greater than the burst frequency, wherein the controller modifies a frequency parameter of the burst stimulation in response to administration of a motor-disorder drug by the patient.
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Accused Products
Abstract
Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient'"'"'s nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
36 Citations
14 Claims
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1. An apparatus for treating a neural condition of a patient, comprising:
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an implantable stimulation lead configured to be positioned to apply electrical stimulation to neural tissue of the patient'"'"'s nervous system, the implantable stimulation lead configured to be implanted in the patient; and an implantable signal generator for generating electrical pulses, the implantable signal generator coupled to the implantable stimulation lead, wherein the implantable signal generator comprises a controller; wherein the controller is configured to direct an application of electrical stimulation to the patient in a manner such that the stimulation has a burst frequency and an intra-burst frequency greater than the burst frequency, wherein the controller modifies a frequency parameter of the burst stimulation in response to administration of a motor-disorder drug by the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An apparatus for treating a neural condition of a patient, comprising:
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an implantable stimulation lead configured to be positioned to apply electrical stimulation to neural tissue of the patient'"'"'s nervous system, the implantable stimulation lead configured to be implanted in the patient; and an implantable signal generator for generating electrical pulses, the implantable signal generator coupled to the implantable stimulation lead, wherein the implantable signal generator comprises a controller; wherein the controller is configured to direct an application of electrical stimulation to the patient in a manner such that the stimulation has a burst frequency and an intra-burst frequency greater than the burst frequency, wherein the controller modifies a frequency parameter of the burst stimulation in response to administration of a motor-disorder drug by the patient, wherein modification of the frequency parameter causes the implantable signal generator to temporarily apply reduced power for applied electrical stimulation. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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Specification