Tubular nanostructure targeted to cell membrane
First Claim
1. An isolated tubular nanostructure comprising:
- a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, anda fourth surface region comprising one or more acetoxymethyl esters and configured to pass through a lipid bilayer membrane of a cell and configured to be degraded by a cytoplasmic component in the cell, wherein the fourth surface region is covalently bound to at least the two hydrophilic surface regions, and the fourth surface region is configured to mask hydrophilicity of the two hydrophilic surface regions.
4 Assignments
0 Petitions
Accused Products
Abstract
Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
56 Citations
56 Claims
-
1. An isolated tubular nanostructure comprising:
-
a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and a fourth surface region comprising one or more acetoxymethyl esters and configured to pass through a lipid bilayer membrane of a cell and configured to be degraded by a cytoplasmic component in the cell, wherein the fourth surface region is covalently bound to at least the two hydrophilic surface regions, and the fourth surface region is configured to mask hydrophilicity of the two hydrophilic surface regions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
-
-
56. A composite tubular nanostructure comprising:
-
two or more nanotubes wherein at least one nanotube includes, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and a fourth surface region comprising one or more acetoxymethyl esters configured to pass through a lipid bilayer membrane of a cell and configured to be degraded by a cytoplasmic component in the cell, wherein the fourth surface region is covalently bound to at least the two hydrophilic surface regions, and the fourth surface region is configured to mask hydrophilicity of the two hydrophilic surface regions.
-
Specification