2′,4′-fluoro nucleosides for the treatment of HCV
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Abstract
Provided herein are compounds, methods and pharmaceutical compositions for use in treatment of viral infections, including hepatitis C virus (HCV) infections, in hosts in need thereof. In certain embodiments, the compounds are 2′,4′-fluoro nucleosides according to Formula 1001:
or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, RA, and PD are as described herein. In certain embodiments, 2′,4′-fluoro nucleosides are provided which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human.
272 Citations
16 Claims
- 1. A compound according to Formula 1001:
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6. A compound according to Formula 1002:
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7. A compound according to Formula 1003:
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8. A compound according to Formula 1004:
Specification