Immunoregulatory peptides and methods of use
First Claim
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1. A method of transporting a compound across a tympanic membrane in an animal in need or want thereof, the method comprising topically administering the compound in a unit dosage form comprising a pharmaceutically acceptable excipient to the tympanic membrane, whereupon the compound crosses the tympanic membrane, wherein the compound is a peptide of any one of SEQ ID NOs:
- 1-369, and 378 conjugated to a transducing sequence at the C-terminus of the peptide.
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Abstract
Peptides for the treatment of inflammation, and therapeutic uses and methods of using the same are disclosed. Peptides including a transducing sequence are effective for inhibiting cytokine activity and TNF-α secretion through interaction with toll-like receptors. Experiments are described illustrating the efficacy of the compounds in treating otitis media.
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33 Claims
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1. A method of transporting a compound across a tympanic membrane in an animal in need or want thereof, the method comprising topically administering the compound in a unit dosage form comprising a pharmaceutically acceptable excipient to the tympanic membrane, whereupon the compound crosses the tympanic membrane, wherein the compound is a peptide of any one of SEQ ID NOs:
- 1-369, and 378 conjugated to a transducing sequence at the C-terminus of the peptide.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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