Method and apparatus for assay of electrochemical properties

• US 9,188,525 B2
• Filed: 02/13/2015
• Issued: 11/17/2015
• Est. Priority Date: 02/10/2002
• Status: Expired due to Term

• Current Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Original Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Inventors: Iyengar, Sridhar G., Harding, Ian S.
• Primary Examiner(s): Noguerola, Alex
• Application Number:
  US14/622,415
• Publication Number:
  US 20150219550A1
• Time in Patent Office: 277 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/04 Arrangements of multiple sensors of the same type
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: G01N 17/02 Electrochemical measuring systems for weathering, corrosion or corrosion-protection measurement
• CPC Class Codes: G01N 27/26 by investigating electrochemical variables; by using electrolysis or electrophoresis
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component.

Claims

1. A method for determining the extent of electrode fouling in an implantable electrochemical sensor comprising at least two electrodes, said method comprising:

applying a potential stimulus to the electrodes to generate a current signal, the potential stimulus comprising a time-varying potential component superimposed on a constant potential component;

isolating a time-varying current component from the current signal;

determining an imaginary part of the time-varying current component, the magnitude of the imaginary part of the time-varying current component being linearly related to the effective electrode area; and

determining the extent of electrode fouling from the determined magnitude of the imaginary part of the time-varying current component.

2. The method of claim 1, further comprising determining a change in effective electrode area as a result of electrode fouling.

3. The method of claim 2, further comprising adjusting a determination of concentration of an analyte based on the change in effective electrode area.

4. The method of claim 3, wherein the adjustment corrects for a decrease in signal intensity due to fouling.

5. The method of claim 3, wherein the adjustment is based on relative changes from initial analyte estimates.

6. The method of claim 3, wherein the adjustment is based on reference to an external data source.

7. The method of claim 6, wherein the external data source comprises one or more calibration curves.

8. The method of claim 7, wherein the calibration curves comprise calibration data gathered from electrodes having different electrode areas.

9. The method of claim 2, further comprising correcting for signal distortion caused by changes in the effective electrode area.

10. The method of claim 1, further comprising adjusting a measured current signal based on the determined extent of electrode fouling.

11. The method of claim 1, further comprising correcting for signal distortion resulting from electrode fouling based on the extent of electrode fouling.